CCL19 and CCL22

Number of citations of the paper that reports this interaction (PMID 15714581)
9

Data Source:
HPRD (in vitro, in vivo)

		CCL19	CCL22
Gene Name		chemokine (C-C motif) ligand 19	chemokine (C-C motif) ligand 22
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Chemokine Activity CCR7 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding	Chemokine Activity
	Biological Process	Establishment Of T Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Cellular Calcium Ion Homeostasis Inflammatory Response Immune Response Cell Communication Activation Of JUN Kinase Activity Response To Virus Positive Regulation Of Glycoprotein Biosynthetic Process T Cell Costimulation Positive Regulation Of Ras GTPase Activity Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Prostaglandin E Positive Regulation Of T Cell Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling Regulation Of Cell Projection Assembly Positive Regulation Of ERK1 And ERK2 Cascade Response To Nitric Oxide Interleukin-12 Secretion Positive Regulation Of Neutrophil Chemotaxis Mature Conventional Dendritic Cell Differentiation Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Dendrite Assembly	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Cell Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ACKR2 ACKR4 CCL22 CCR10 CCR7 CXCL13	7 interactors: CCL19 CCR4 CRYAB DPP4 GCLC HERC3 VCAM1
Entrez ID		6363	6367
HPRD ID		03750	04263
Ensembl ID		ENSG00000172724	ENSG00000102962
Uniprot IDs		Q6IBD6 Q99731	O00626
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Chemotaxis Inflammatory Response Cytokine-mediated Signaling Pathway Locomotion Immune Response Cellular Response To Cytokine Stimulus Response To Cytokine Response To External Stimulus Immune System Process G-protein Coupled Receptor Signaling Pathway Defense Response Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Chemotaxis Cytosolic Calcium Ion Homeostasis Neutrophil Activation Cellular Response To Organic Substance Lymphocyte Migration Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Humoral Immune Response Receptor-mediated Endocytosis Response To Organic Substance Activation Of Ras GTPase Activity Cellular Metal Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Cellular Cation Homeostasis Signal Transduction Cellular Ion Homeostasis Metal Ion Homeostasis Leukocyte Activation Signaling Positive Regulation Of Leukocyte Migration Cell Communication Cellular Chemical Homeostasis Cell Surface Receptor Signaling Pathway Ion Homeostasis Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-C Motif) Ligand 19 Signaling Pathway Lymphocyte Chemotaxis Across High Endothelial Venule Positive Regulation Of Immunological Synapse Formation Endothelial Cell Chemotaxis To Fibroblast Growth Factor B Cell Chemotaxis Across High Endothelial Venule Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Lymphocyte Migration Into Lymph Node Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Response To Stress	Response To Abiotic Stimulus Positive Regulation Of T Cell Activation Cellular Homeostasis Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Proliferation Cell Migration Response To Lipid Response To Stress Response To Hypoxia Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cell Motility Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Lymphocyte Activation Response To Oxidative Stress Inflammatory Response T Cell Costimulation Response To Radiation Response To Organic Substance Locomotion Response To Inorganic Substance Regulation Of Cell Activation Positive Regulation Of T Cell Proliferation Leukocyte Activation Positive Regulation Of Dendritic Cell Dendrite Assembly Homeostatic Process Single Organismal Cell-cell Adhesion Cellular Chemical Homeostasis Positive Regulation Of Chemotaxis Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Stress-activated MAPK Cascade Positive Regulation Of Lymphocyte Proliferation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Mononuclear Cell Proliferation Chemotaxis Regulation Of Cell Adhesion Positive Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Activation Response To Ionizing Radiation Regulation Of T Cell Proliferation Immune System Development Myeloid Dendritic Cell Chemotaxis Regulation Of Dendritic Cell Dendrite Assembly
Tagcloud ?		aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl20 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger	27cm3 39cm3 alternatively capacities cd163 considering correlate cultivation documented emt hazard hcc hepatocellular infiltration injuries invasiveness m2 macrophage macrophages mesenchymal mhcc97l nodules orthotopic proven quantified scavenger snail tumour venous
Tagcloud (Difference) ?		aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl20 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger	27cm3 39cm3 alternatively capacities cd163 considering correlate cultivation documented emt hazard hcc hepatocellular infiltration injuries invasiveness m2 macrophage macrophages mesenchymal mhcc97l nodules orthotopic proven quantified scavenger snail tumour venous
Tagcloud (Intersection) ?