CCR7 and CCR10

Number of citations of the paper that reports this interaction (PMID 10706668)
23

Data Source:
HPRD (in vitro)

		CCR7	CCR10
Gene Name		chemokine (C-C motif) receptor 7	chemokine (C-C motif) receptor 10
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	G-protein Coupled Receptor Activity C-C Chemokine Receptor Activity Chemokine (C-C Motif) Ligand 19 Binding Chemokine (C-C Motif) Ligand 21 Binding C-C Motif Chemokine 19 Receptor Activity C-C Motif Chemokine 21 Receptor Activity	G-protein Coupled Receptor Activity C-C Chemokine Receptor Activity
	Biological Process	Establishment Of T Cell Polarity Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Hypersensitivity Positive Regulation Of Humoral Immune Response Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Ruffle Organization Response To Lipopolysaccharide Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Activation Of Rho GTPase Activity Response To Prostaglandin E Chemokine (C-C Motif) Ligand 19 Signaling Pathway Chemokine (C-C Motif) Ligand 21 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Thymic T Cell Selection Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of T Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Response To Nitric Oxide Interleukin-12 Secretion Positive Regulation Of Neutrophil Chemotaxis Lymphocyte Migration Into Lymph Node Mature Conventional Dendritic Cell Differentiation Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of Immunological Synapse Formation Positive Regulation Of T Cell Costimulation Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Regulation Of Dendritic Cell Dendrite Assembly	Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CCL19 CCL21 CCR10	10 interactors: CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL7 CCR7 CXCL13 PRRC2A
Entrez ID		1236	2826
HPRD ID		02588	02586
Ensembl ID		ENSG00000126353
Uniprot IDs		A0N0Q0 P32248	P46092
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Dendritic Cell Dendrite Assembly Establishment Of T Cell Polarity Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Cytosolic Calcium Ion Homeostasis Dendritic Cell Chemotaxis Immunological Synapse Formation Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Glycoprotein Metabolic Process Response To Prostaglandin E Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Neutrophil Chemotaxis Dendritic Cell Migration Positive Regulation Of Granulocyte Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Glycoprotein Biosynthetic Process Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Cellular Metal Ion Homeostasis Inflammatory Response Cellular Cation Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Granulocyte Chemotaxis Cellular Ion Homeostasis Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Sequestering Of Calcium Ion Metal Ion Homeostasis Leukocyte Activation Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Cellular Chemical Homeostasis Regulation Of Phosphatidylinositol 3-kinase Activity Ion Homeostasis Negative Regulation Of Leukocyte Apoptotic Process Chemotaxis Regulation Of Lipid Kinase Activity Cell-cell Recognition Positive Regulation Of Leukocyte Chemotaxis Cell Activation Cellular Homeostasis Response To Fatty Acid T Cell Costimulation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Leukocyte Migration Chemical Homeostasis Leukocyte Chemotaxis Positive Regulation Of Endocytosis Positive Regulation Of Chemotaxis Establishment Of Cell Polarity	Cell Chemotaxis Regulation Of Leukocyte Migration Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Cell Migration Positive Regulation Of Leukocyte Migration Cell Motility Leukocyte Migration Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Cell Migration Cellular Calcium Ion Homeostasis Positive Regulation Of Behavior Calcium Ion Homeostasis Regulation Of Cell Motility Regulation Of Chemotaxis Locomotion Regulation Of Locomotion Immune Response Regulation Of Cellular Component Movement Positive Regulation Of Cell Adhesion Cellular Metal Ion Homeostasis Movement Of Cell Or Subcellular Component Regulation Of Behavior Inflammatory Response Cellular Cation Homeostasis Regulation Of Dendritic Cell Dendrite Assembly Cellular Ion Homeostasis Metal Ion Homeostasis Negative Regulation Of Leukocyte Migration Cellular Chemical Homeostasis Response To External Stimulus Negative Regulation Of Leukocyte Tethering Or Rolling Ion Homeostasis Regulation Of Cell Adhesion Regulation Of Lymphocyte Migration Immune System Process Regulation Of Granulocyte Chemotaxis Positive Regulation Of Cell Migration Establishment Of T Cell Polarity Positive Regulation Of Cell Motility Cellular Homeostasis Regulation Of Immune System Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Cell-cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Chemical Homeostasis Positive Regulation Of Cell-matrix Adhesion
Tagcloud ?		capture ccr1 ccr2 ccr5 cd40 chemokine chemokines cxcr1 cxcr4 dc dendritic ebi1 elc immature inflamed insight lost lymphoid marginally maturation mature maturing migrate nodes organs phases respective responded responsiveness	allograft allografts alloreactivity archived arrays augur cd138 cd154 cd19 cd27 existed ig iga igg igll1 immunocyte immunocytes intestine itx mucosal prone protracted reconstitution rejecting rejection repopulation serial stap1 undergoes
Tagcloud (Difference) ?		capture ccr1 ccr2 ccr5 cd40 chemokine chemokines cxcr1 cxcr4 dc dendritic ebi1 elc immature inflamed insight lost lymphoid marginally maturation mature maturing migrate nodes organs phases respective responded responsiveness	allograft allografts alloreactivity archived arrays augur cd138 cd154 cd19 cd27 existed ig iga igg igll1 immunocyte immunocytes intestine itx mucosal prone protracted reconstitution rejecting rejection repopulation serial stap1 undergoes
Tagcloud (Intersection) ?