CLNK and LCP2

Number of citations of the paper that reports this interaction (PMID 10562326)
12

Data Source:
HPRD (in vitro)

		CLNK	LCP2
Gene Name		cytokine-dependent hematopoietic cell linker	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular	Cytosol Cell-cell Junction
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Protein Binding
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signal Transduction	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Platelet Activation Fc-epsilon Receptor Signaling Pathway Innate Immune Response Mast Cell Activation Cytokine Secretion T Cell Receptor Signaling Pathway
Pathways			DAP12 interactions Generation of second messenger molecules FCERI mediated MAPK activation DAP12 signaling TCR signaling GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS		Vitiligo ( 22561518)
Protein-Protein Interactions		3 interactors: EGFR ERBB2 LCP2	39 interactors: APP BLNK CBL CD22 CLNK FXR2 FYB FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LYN MAP4K1 NCK1 NCK2 PAG1 PIK3R1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAZ ZAP70
Entrez ID		116449	3937
HPRD ID		14720	03362
Ensembl ID
Uniprot IDs		Q7Z7G1	Q13094
PDB IDs			1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?		Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Alkanesulfonate Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Glial Cell Differentiation Defense Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Protein Autophosphorylation Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Neurotrophin Signaling Pathway Gliogenesis Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Regulation Of Epithelial Cell Proliferation Regulation Of MAP Kinase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Activation Of Phospholipase A2 Activity Positive Regulation Of Phospholipase A2 Activity Response To Cobalamin Response To UV-A Immune System Process Axon Guidance Response To Hydroxyisoflavone Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Negative Regulation Of T Cell Differentiation In Thymus Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription From RNA Polymerase III Promoter Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Kinase Activity Positive Regulation Of Transcription From RNA Polymerase I Promoter	Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Cell Activation Immune System Process Immune Response Positive Regulation Of Signal Transduction Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Innate Immune Response Defense Response Fc-epsilon Receptor Signaling Pathway Platelet Activation Regulation Of Signal Transduction Leukocyte Activation Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Signaling Blood Coagulation Signal Transduction Hemostasis Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cell Activation Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Signaling Leukocyte Migration Lymphocyte Activation Cell Communication Positive Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Regulation Of Body Fluid Levels Positive Regulation Of Cell Adhesion Wound Healing Regulation Of Cell Adhesion Peptidyl-tyrosine Autophosphorylation
Tagcloud ?			aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70
Tagcloud (Difference) ?			aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70
Tagcloud (Intersection) ?