LCP2 and TRAT1

Number of citations of the paper that reports this interaction (PMID 10790433)
107

Data Source:
BioGRID (pull down)

		LCP2	TRAT1
Gene Name		lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	T cell receptor associated transmembrane adaptor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cell-cell Junction	Plasma Membrane Integral Component Of Plasma Membrane T Cell Receptor Complex
	Molecular Function	Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Platelet Activation Fc-epsilon Receptor Signaling Pathway Innate Immune Response Mast Cell Activation Cytokine Secretion T Cell Receptor Signaling Pathway	Negative Regulation Of Receptor Recycling Cellular Defense Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Transport
Pathways		DAP12 interactions Generation of second messenger molecules FCERI mediated MAPK activation DAP12 signaling TCR signaling GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Innate Immune System Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Downstream TCR signaling Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR TCR signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		39 interactors: APP BLNK CBL CD22 CLNK FXR2 FYB FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LYN MAP4K1 NCK1 NCK2 PAG1 PIK3R1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAZ ZAP70	11 interactors: CD247 CD3E FYN GRB2 LCK LCP2 LYN PIK3R1 SRC TRA TRB
Entrez ID		3937	50852
HPRD ID		03362	05392
Ensembl ID			ENSG00000163519
Uniprot IDs		Q13094	Q6PIZ9
PDB IDs		1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Cell Activation Immune System Process Immune Response Positive Regulation Of Signal Transduction Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Innate Immune Response Defense Response Fc-epsilon Receptor Signaling Pathway Platelet Activation Regulation Of Signal Transduction Leukocyte Activation Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Signaling Blood Coagulation Signal Transduction Hemostasis Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cell Activation Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Signaling Leukocyte Migration Lymphocyte Activation Cell Communication Positive Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Regulation Of Body Fluid Levels Positive Regulation Of Cell Adhesion Wound Healing Regulation Of Cell Adhesion Peptidyl-tyrosine Autophosphorylation	T Cell Costimulation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Positive Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Platelet Activation Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cell Activation T Cell Receptor Signaling Pathway Regulation Of Cell Adhesion Cell Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Innate Immune Response Blood Coagulation Hemostasis Enzyme Linked Receptor Protein Signaling Pathway Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Viral Process Phagocytosis Regulation Of Body Fluid Levels Wound Healing Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Immune System Process Response To Wounding Immune Response Peptidyl-tyrosine Autophosphorylation Defense Response Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Peptide Hormone Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor
Tagcloud ?		aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70
Tagcloud (Difference) ?		aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70
Tagcloud (Intersection) ?