LCP2 and TXK

Number of citations of the paper that reports this interaction (PMID 8702662)
66

Data Source:
HPRD (in vitro, in vivo)

		LCP2	TXK
Gene Name		lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	TXK tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cell-cell Junction	Nucleus Cytoplasm Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Platelet Activation Fc-epsilon Receptor Signaling Pathway Innate Immune Response Mast Cell Activation Cytokine Secretion T Cell Receptor Signaling Pathway	Cytokine Production NK T Cell Differentiation Adaptive Immune Response Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity T Cell Differentiation Interferon-gamma Production Interleukin-4 Production Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways		DAP12 interactions Generation of second messenger molecules FCERI mediated MAPK activation DAP12 signaling TCR signaling GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Innate Immune System Adaptive Immune System	Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System
Drugs
Diseases
GWAS			Crohn's disease ( 23128233)
Protein-Protein Interactions		39 interactors: APP BLNK CBL CD22 CLNK FXR2 FYB FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LYN MAP4K1 NCK1 NCK2 PAG1 PIK3R1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAZ ZAP70	10 interactors: CCR5 CTLA4 ERBB2 ERBB3 FYN LCP2 NELFCD SH2D2A SRC YTHDC1
Entrez ID		3937	7294
HPRD ID		03362	02505
Ensembl ID			ENSG00000074966
Uniprot IDs		Q13094	P42681
PDB IDs		1H3H 1YWO 2EAP 2ROR	2DM0
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Cell Activation Immune System Process Immune Response Positive Regulation Of Signal Transduction Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Innate Immune Response Defense Response Fc-epsilon Receptor Signaling Pathway Platelet Activation Regulation Of Signal Transduction Leukocyte Activation Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Signaling Blood Coagulation Signal Transduction Hemostasis Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cell Activation Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Signaling Leukocyte Migration Lymphocyte Activation Cell Communication Positive Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Regulation Of Body Fluid Levels Positive Regulation Of Cell Adhesion Wound Healing Regulation Of Cell Adhesion Peptidyl-tyrosine Autophosphorylation	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Wound Healing Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation T Cell Costimulation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Immune System Process Immune System Process Response To Wounding Defense Response Cellular Response To Platelet-derived Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Innate Immune Response Response To Platelet-derived Growth Factor Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Activation Phosphatidylinositol 3-kinase Signaling Viral Process Platelet Activation Cellular Response To Growth Factor Stimulus Protein Autophosphorylation Response To Growth Factor Chemotaxis Positive Regulation Of T Cell Activation Positive Regulation Of Signal Transduction Negative Regulation Of T Cell Differentiation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Immune Response Leukocyte Migration
Tagcloud ?		aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70	abl abundant acting bcr bmx brdg1 btk constitute docking downstream effectors feature feedback homology integrins itk lyn participate ph pleckstrin proline ptks pyk2 ramos sh2 syk tec termed triggered
Tagcloud (Difference) ?		aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 kif2c limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70	abl abundant acting bcr bmx brdg1 btk constitute docking downstream effectors feature feedback homology integrins lyn participate ph pleckstrin proline ptks pyk2 ramos sh2 syk tec termed triggered
Tagcloud (Intersection) ?		itk