RNF139 and UBE2Z

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		RNF139	UBE2Z
Gene Name		ring finger protein 139	ubiquitin-conjugating enzyme E2Z
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleoplasm Cytoplasm
	Molecular Function	Protease Binding Ubiquitin-protein Transferase Activity Receptor Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin-like Protein Transferase Activity	Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Cell Proliferation Protein Ubiquitination Negative Regulation Of Translation Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Protein Processing Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination Apoptotic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Coronary heart disease ( 21378990)
Protein-Protein Interactions		6 interactors: COPS5 EIF3A UBE2H UBE2U UBE2Z VHL	31 interactors: AK8 BMPR1B DZIP3 HLTF HMBOX1 LNX2 LPL MDM2 PLEKHF2 PPP1CA RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM46 TRIM65 UBA6 UBD
Entrez ID		11236	65264
HPRD ID		04333	08589
Ensembl ID			ENSG00000159202
Uniprot IDs		Q8WU17	Q9H832
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Proteolysis Cellular Protein Modification Process Exosomal Secretion Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Mature Ribosome Assembly Cullin Deneddylation Ribosomal Subunit Export From Nucleus Cytoplasmic Translational Initiation Protein Deneddylation Cytoplasmic Translation Posttranscriptional Regulation Of Gene Expression Formation Of Translation Preinitiation Complex Protein K11-linked Ubiquitination Ribosomal Large Subunit Biogenesis Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Modification-dependent Protein Catabolic Process Ribosome Assembly Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Histone Ubiquitination Protein Catabolic Process Protein K48-linked Ubiquitination Translation	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Regulation Of Cell Death Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Cellular Macromolecule Catabolic Process Protein Destabilization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway ER-associated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Apoptotic Process Endothelial Cell Activation Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of SMAD Protein Import Into Nucleus Apoptotic Process Negative Regulation Of Cell Proliferation SMAD Protein Complex Assembly BMP Signaling Pathway Regulation Of SMAD Protein Import Into Nucleus Programmed Cell Death Cell Death Death Regulation Of Cartilage Development Response To Stress Proteasomal Protein Catabolic Process Proteolysis Triglyceride Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Gene Expression Regulation Of Signaling Cardiac Epithelial To Mesenchymal Transition Acylglycerol Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Response To Growth Factor Negative Regulation Of Gene Expression Positive Regulation Of Programmed Cell Death Metabolic Process
Tagcloud ?		11q 16p 16q 17p 17q 18q 19q 2q 3q 4q 6p 8p 8q 9p arrange casp1 cdkn2d cttn fgf3 il12b imbalances macroscopically mlpa mme mvp nfkb1 ptk2 ptp4a3 tusc3	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2n ube2q1 ubiquitin ubiquitination
Tagcloud (Difference) ?		11q 16p 16q 17p 17q 18q 19q 2q 3q 4q 6p 8p 8q 9p arrange casp1 cdkn2d cttn fgf3 il12b imbalances macroscopically mlpa mme mvp nfkb1 ptk2 ptp4a3 tusc3	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2n ube2q1 ubiquitin ubiquitination
Tagcloud (Intersection) ?