UBE2Z and RNF130

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		UBE2Z	RNF130
Gene Name		ubiquitin-conjugating enzyme E2Z	ring finger protein 130
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Integral Component Of Membrane
	Molecular Function	Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity
	Biological Process	Protein Polyubiquitination Apoptotic Process	Apoptotic Process Programmed Cell Death Protein Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Coronary heart disease ( 21378990)	Coronary heart disease ( 21347282)
Protein-Protein Interactions		31 interactors: AK8 BMPR1B DZIP3 HLTF HMBOX1 LNX2 LPL MDM2 PLEKHF2 PPP1CA RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM46 TRIM65 UBA6 UBD	13 interactors: ARPC4 FGFR3 SCN2A TGFBR1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2Z
Entrez ID		65264	55819
HPRD ID		08589	11504
Ensembl ID		ENSG00000159202	ENSG00000113269
Uniprot IDs		Q9H832	J3KN31 Q2HIY3 Q59EL1 Q86XS8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Regulation Of Cell Death Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Cellular Macromolecule Catabolic Process Protein Destabilization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway ER-associated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Apoptotic Process Endothelial Cell Activation Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of SMAD Protein Import Into Nucleus Apoptotic Process Negative Regulation Of Cell Proliferation SMAD Protein Complex Assembly BMP Signaling Pathway Regulation Of SMAD Protein Import Into Nucleus Programmed Cell Death Cell Death Death Regulation Of Cartilage Development Response To Stress Proteasomal Protein Catabolic Process Proteolysis Triglyceride Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Gene Expression Regulation Of Signaling Cardiac Epithelial To Mesenchymal Transition Acylglycerol Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Response To Growth Factor Negative Regulation Of Gene Expression Positive Regulation Of Programmed Cell Death Metabolic Process	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Immune Response-regulating Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Protein Modification Process Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Innate Immune Response Regulation Of Immune Response Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Modification-dependent Protein Catabolic Process Cellular Response To Hypoxia Protein K11-linked Ubiquitination Cellular Response To Decreased Oxygen Levels Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Cellular Response To Oxygen Levels Protein Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Immune Response Protein K63-linked Ubiquitination Transforming Growth Factor Beta Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Negative Regulation Of Mitotic Nuclear Division Defense Response Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Cell Cycle Cellular Macromolecule Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2n ube2q1 ubiquitin ubiquitination
Tagcloud (Difference) ?		array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2n ube2q1 ubiquitin ubiquitination
Tagcloud (Intersection) ?