RNF139 and UBE2U

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		RNF139	UBE2U
Gene Name		ring finger protein 139	ubiquitin-conjugating enzyme E2U (putative)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nuclear Chromatin Cytoplasm HULC Complex
	Molecular Function	Protease Binding Ubiquitin-protein Transferase Activity Receptor Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin-like Protein Transferase Activity	ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Cell Proliferation Protein Ubiquitination Negative Regulation Of Translation Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Protein Processing Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: COPS5 EIF3A UBE2H UBE2U UBE2Z VHL	66 interactors: ANAPC11 BARD1 BFAR CADPS2 CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 VPS11 VPS41 ZSWIM2
Entrez ID		11236	148581
HPRD ID		04333	14599
Ensembl ID			ENSG00000177414
Uniprot IDs		Q8WU17	Q5VVX9
PDB IDs			1YRV
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Proteolysis Cellular Protein Modification Process Exosomal Secretion Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Mature Ribosome Assembly Cullin Deneddylation Ribosomal Subunit Export From Nucleus Cytoplasmic Translational Initiation Protein Deneddylation Cytoplasmic Translation Posttranscriptional Regulation Of Gene Expression Formation Of Translation Preinitiation Complex Protein K11-linked Ubiquitination Ribosomal Large Subunit Biogenesis Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Modification-dependent Protein Catabolic Process Ribosome Assembly Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Histone Ubiquitination Protein Catabolic Process Protein K48-linked Ubiquitination Translation	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Negative Regulation Of Viral Release From Host Cell Protein Metabolic Process Regulation Of Viral Release From Host Cell Protein Polyubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Process Protein Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Innate Immune Response Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Macromolecule Catabolic Process Regulation Of Protein Stability Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination Regulation Of Gene Expression Histone H2A Ubiquitination Histone H2A-K119 Monoubiquitination Immune Response Regulation Of Intracellular Transport Cellular Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Defense Response Interferon-gamma-mediated Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Response To Stress Negative Regulation Of Viral Transcription Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Cellular Response To Interferon-gamma Protein Destabilization Regulation Of Signal Transduction
Tagcloud ?		11q 16p 16q 17p 17q 18q 19q 2q 3q 4q 6p 8p 8q 9p arrange casp1 cdkn2d cttn fgf3 il12b imbalances macroscopically mlpa mme mvp nfkb1 ptk2 ptp4a3 tusc3
Tagcloud (Difference) ?		11q 16p 16q 17p 17q 18q 19q 2q 3q 4q 6p 8p 8q 9p arrange casp1 cdkn2d cttn fgf3 il12b imbalances macroscopically mlpa mme mvp nfkb1 ptk2 ptp4a3 tusc3
Tagcloud (Intersection) ?