KIF3A and MAP3K11

Number of citations of the paper that reports this interaction (PMID 9427749)
54

Data Source:
HPRD (in vivo, two hybrid)

		KIF3A	MAP3K11
Gene Name		kinesin family member 3A	mitogen-activated protein kinase kinase kinase 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Cytosol Spindle Microtubule Microtubule Cytoskeleton Kinesin II Complex Extracellular Vesicular Exosome Primary Cilium Ciliary Tip	Cytoplasm Centrosome Microtubule Membrane
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Spectrin Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity Rac GTPase Binding
	Biological Process	Organelle Organization Microtubule-based Movement Blood Coagulation Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neurogenesis Cilium Assembly Cilium Morphogenesis Membrane Organization Plus-end-directed Vesicle Transport Along Microtubule	Activation Of MAPK Activity Protein Phosphorylation Microtubule-based Process JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Cell Death Cell Proliferation Peptidyl-tyrosine Phosphorylation Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		Organelle biogenesis and maintenance Hedgehog 'off' state Kinesins Translocation of GLUT4 to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Intraflagellar transport Hedgehog 'on' state MHC class II antigen presentation Signaling by Hedgehog Adaptive Immune System Activation of SMO
Drugs
Diseases
GWAS		Atopic dermatitis ( 23042114 22197932)
Protein-Protein Interactions		13 interactors: APP DISC1 GRB2 KIF3B KIF3C LIG4 MAP3K10 MAP3K11 NEK1 PLEKHA5 PPP1R15A RPGR VHL	27 interactors: AKT1 APP CDC42 CHUK CLEC4G COPS5 EPS8 IKBKB KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP2K7 MAP3K12 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 PIN1 RAC1 RHOG SH3RF1 STUB1 TRAF6 UBC
Entrez ID		11127	4296
HPRD ID		05250	02502
Ensembl ID		ENSG00000131437	ENSG00000173327
Uniprot IDs		E9PES4 J3KPF9 Q05CT3 Q9Y496	Q16584
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule-based Transport Response To Stress Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Cellular Response To Stress Activation Of JNKK Activity Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Microtubule-based Movement Positive Regulation Of Protein Metabolic Process Response To Stimulus Regulation Of Phosphorylation Activation Of MAPK Activity Response To Ionizing Radiation Blood Coagulation Hemostasis Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Protein Modification Process Response To Radiation Positive Regulation Of Catalytic Activity Cell Death Death Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of MAP Kinase Activity Regulation Of Body Fluid Levels Activation Of JUN Kinase Activity MAPK Cascade Wound Healing Regulation Of Signal Transduction Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Axon Cargo Transport Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Organelle Transport Along Microtubule Signal Transduction By Phosphorylation Response To Wounding Neuron Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Signaling Regulation Of Protein Kinase Activity Developmental Process Activation Of MAPKK Activity Regulation Of Protein Metabolic Process	Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade JNK Cascade Regulation Of MAPK Cascade Regulation Of Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Transferase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Phosphorylation Response To Stress Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Kinase Activity MAPK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Kinase Activity Signal Transduction By Phosphorylation Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Protein Metabolic Process Regulation Of JUN Kinase Activity Fc Receptor Signaling Pathway Innate Immune Response Positive Regulation Of MAPK Cascade Signal Transduction Toll-like Receptor 5 Signaling Pathway Positive Regulation Of Metabolic Process Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Protein Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Immune System Process Toll-like Receptor 2 Signaling Pathway Positive Regulation Of JNK Cascade Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		aberrant activate advanced anchorage axis benign biopsies catenin causal ck1 correlate dvl2 exogenous gleason hef1 inactivation kinesin mechanistically mmp9 node notion promoted prostate rarely silencing transactivation upregulated upregulation wnt	acceleration activate agar besides carcinogenesis cdk2 colony crkl cycle cycling1 facilitate g1 htert mb mda methylate methyltransferase mynd oncogenes phenotypes pik3cb riz set smyd3 soft stat1 transduction transformed wnt10b
Tagcloud (Difference) ?		aberrant advanced anchorage axis benign biopsies catenin causal ck1 correlate dvl2 exogenous gleason hef1 inactivation kinesin mechanistically mmp9 node notion promoted prostate rarely silencing transactivation upregulated upregulation wnt	acceleration agar besides carcinogenesis cdk2 colony crkl cycle cycling1 facilitate g1 htert mb mda methylate methyltransferase mynd oncogenes phenotypes pik3cb riz set smyd3 soft stat1 transduction transformed wnt10b
Tagcloud (Intersection) ?		activate