RNPS1 and SRP54

Number of citations of the paper that reports this interaction (PMID 14729963)
24

Data Source:
HPRD (two hybrid, in vivo)

		RNPS1	SRP54
Gene Name		RNA binding protein S1, serine-rich domain	signal recognition particle 54kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Exon-exon Junction Complex ASAP Complex	Nucleus Nucleolus Cytoplasm Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Nuclear Speck
	Molecular Function	Nucleotide Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) RNA Binding	GTPase Activity GTP Binding Drug Binding 7S RNA Binding GDP Binding Endoplasmic Reticulum Signal Peptide Binding Ribonucleoprotein Complex Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Positive Regulation Of Apoptotic Process Negative Regulation Of MRNA Splicing, Via Spliceosome	Translation SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Gene Expression Response To Drug Cellular Protein Metabolic Process Protein Targeting To ER
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing	Translation SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ACIN1 CHERP CLK2 DVL2 HEXIM2 HOXD4 LUC7L3 NKTR PIN1 PNN PRPF38A RBM8A SAP18 SART3 SDCBP2 SRP54 SRPK1 SRPK2 SRSF1 SRSF11 SRSF4 SRSF6 TAF2 TRA2A TRA2B TRIM41 U2AF1 UBQLN4 UPF2 YWHAB YWHAG ZBTB14 ZNF473 ZNF490	2 interactors: RNPS1 SRP19
Entrez ID		10921	6729
HPRD ID		07341	05330
Ensembl ID		ENSG00000205937	ENSG00000100883
Uniprot IDs		D3DU92 Q15287	P61011
PDB IDs		4A8X	1MFQ 1QB2
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Splicing RNA Processing Gene Expression Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Splicing, Via Spliceosome RNA Metabolic Process Regulation Of MRNA Processing Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA 3'-end Processing Nuclear Export MRNA Transport Nitrogen Compound Metabolic Process RNA Transport RNA Localization Cellular Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleocytoplasmic Transport Nuclear Transport Transcription, DNA-templated RNA Biosynthetic Process Cytoplasmic Transport Intracellular Transport Regulation Of Gene Expression Spliceosomal Complex Assembly Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Ribonucleoprotein Complex Assembly Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Establishment Of Localization In Cell Cellular Localization Macromolecule Biosynthetic Process Regulation Of Metabolic Process MRNA Splice Site Selection Metabolic Process Ribonucleoprotein Complex Biogenesis	Cytoplasmic Transport Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Alternative MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription Intracellular Transport Regulation Of MRNA Splicing, Via Spliceosome MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Establishment Of Localization In Cell Regulation Of MRNA Processing SRP-dependent Cotranslational Protein Targeting To Membrane Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of RNA Splicing RNA 3'-end Processing Nuclear Export MRNA Transport Protein Localization To Endoplasmic Reticulum Cellular Localization RNA Transport Nuclear-transcribed MRNA Catabolic Process RNA Localization MRNA Catabolic Process Protein Targeting To Membrane RNA Catabolic Process
Tagcloud ?		acinus bcl constructs corepressor demonstrates driven enhances explored inc isoforms manner minigene periodicals physiol promoters ra rar rarbeta repressed responsive retinoic rrm splice splicing stimulates varying weak weaker wiley	abrupt bip cerevisiae coincident cytoplasmic depleted disulfide doublings drastically fall foldase hann homolog hsp104 hsp70 hsp82 isomerase participate precursors resident saccharomyces secretory slowing stressors unlike untranslocated walter ydj1p
Tagcloud (Difference) ?		acinus bcl constructs corepressor demonstrates driven enhances explored inc isoforms manner minigene periodicals physiol promoters ra rar rarbeta repressed responsive retinoic rrm splice splicing stimulates varying weak weaker wiley	abrupt bip cerevisiae coincident cytoplasmic depleted disulfide doublings drastically fall foldase hann homolog hsp104 hsp70 hsp82 isomerase participate precursors resident saccharomyces secretory slowing stressors unlike untranslocated walter ydj1p
Tagcloud (Intersection) ?