RNPS1 and SRSF1

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		RNPS1	SRSF1
Gene Name		RNA binding protein S1, serine-rich domain	serine/arginine-rich splicing factor 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Exon-exon Junction Complex ASAP Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	Nucleotide Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) RNA Binding	Nucleotide Binding RNA Binding MRNA Binding Protein Binding Poly(A) RNA Binding RS Domain Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Positive Regulation Of Apoptotic Process Negative Regulation Of MRNA Splicing, Via Spliceosome	MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection MRNA Processing MRNA Export From Nucleus Regulation Of Translation RNA Splicing Gene Expression MRNA 3'-end Processing Regulation Of MRNA Stability Regulation Of MRNA Splicing, Via Spliceosome Cardiac Muscle Contraction
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing	mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ACIN1 CHERP CLK2 DVL2 HEXIM2 HOXD4 LUC7L3 NKTR PIN1 PNN PRPF38A RBM8A SAP18 SART3 SDCBP2 SRP54 SRPK1 SRPK2 SRSF1 SRSF11 SRSF4 SRSF6 TAF2 TRA2A TRA2B TRIM41 U2AF1 UBQLN4 UPF2 YWHAB YWHAG ZBTB14 ZNF473 ZNF490	41 interactors: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDK12 CDK6 CLK1 DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF2 SRSF4 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2
Entrez ID		10921	6426
HPRD ID		07341	02887
Ensembl ID		ENSG00000205937
Uniprot IDs		D3DU92 Q15287	Q07955 Q59FA2
PDB IDs		4A8X	1X4A 2M7S 2M8D 2O3D 3BEG
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Splicing RNA Processing Gene Expression Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Splicing, Via Spliceosome RNA Metabolic Process Regulation Of MRNA Processing Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA 3'-end Processing Nuclear Export MRNA Transport Nitrogen Compound Metabolic Process RNA Transport RNA Localization Cellular Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleocytoplasmic Transport Nuclear Transport Transcription, DNA-templated RNA Biosynthetic Process Cytoplasmic Transport Intracellular Transport Regulation Of Gene Expression Spliceosomal Complex Assembly Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Ribonucleoprotein Complex Assembly Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Establishment Of Localization In Cell Cellular Localization Macromolecule Biosynthetic Process Regulation Of Metabolic Process MRNA Splice Site Selection Metabolic Process Ribonucleoprotein Complex Biogenesis	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Regulation Of RNA Splicing Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process MRNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Export From Nucleus Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of MRNA Processing Ribonucleoprotein Complex Assembly MRNA Transport Nuclear Export Termination Of RNA Polymerase II Transcription Nucleocytoplasmic Transport Nuclear Transport MRNA 3'-end Processing RNA Transport RNA Localization RNA 3'-end Processing DNA-templated Transcription, Termination Negative Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Biogenesis Negative Regulation Of RNA Splicing Cellular Metabolic Process MRNA Splice Site Selection Transcription From RNA Polymerase II Promoter Cytoplasmic Transport Cellular Macromolecular Complex Assembly Metabolic Process Cellular Component Assembly Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated Establishment Of Localization In Cell RNA Biosynthetic Process Intracellular Transport Regulation Of Nitrogen Compound Metabolic Process Cellular Localization Positive Regulation Of Gene Expression Peptidyl-threonine Phosphorylation
Tagcloud ?		acinus bcl constructs corepressor demonstrates driven enhances explored inc isoforms manner minigene periodicals physiol promoters ra rar rarbeta repressed responsive retinoic rrm splice splicing stimulates varying weak weaker wiley	altering c16 c24 c6 ceramide ceramides deleted deletion dephosphorylated disclose eliminate exogenous exon heterozygous introducing lose posttranscriptional preferentially restore restored restores restoring sensitizes ser15 sphingolipids splicing stabilizing translocated unrecognized
Tagcloud (Difference) ?		acinus bcl constructs corepressor demonstrates driven enhances explored inc isoforms manner minigene periodicals physiol promoters ra rar rarbeta repressed responsive retinoic rrm splice stimulates varying weak weaker wiley	altering c16 c24 c6 ceramide ceramides deleted deletion dephosphorylated disclose eliminate exogenous exon heterozygous introducing lose posttranscriptional preferentially restore restored restores restoring sensitizes ser15 sphingolipids stabilizing translocated unrecognized
Tagcloud (Intersection) ?		splicing