RRAGA and RPTOR

Number of citations of the paper that reports this interaction (PMID 18497260)
364

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)

		RRAGA	RPTOR
Gene Name		Ras-related GTP binding A	regulatory associated protein of MTOR, complex 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus EGO Complex Intracellular Membrane-bounded Organelle Gtr1-Gtr2 GTPase Complex	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Dendrite TORC1 Complex Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Homodimerization Activity Protein Heterodimerization Activity Phosphoprotein Binding	RNA Polymerase III Type 1 Promoter DNA Binding RNA Polymerase III Type 2 Promoter DNA Binding RNA Polymerase III Type 3 Promoter DNA Binding TFIIIC-class Transcription Factor Binding Protein Binding Protein Kinase Binding Protein Complex Binding 14-3-3 Protein Binding
	Biological Process	Apoptotic Process Cell Death Cellular Response To Starvation Regulation Of Autophagy Modulation By Virus Of Host Morphology Or Physiology Positive Regulation Of TOR Signaling Cellular Protein Localization Positive Regulation Of Cytolysis Cellular Response To Amino Acid Stimulus	Positive Regulation Of Endothelial Cell Proliferation Cell Cycle Arrest Insulin Receptor Signaling Pathway Regulation Of Cell Size Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Cellular Response To Heat Positive Regulation Of Transcription From RNA Polymerase III Promoter Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat
Pathways			IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade IRS-related events triggered by IGF1R HSF1-dependent transactivation Release of eIF4E Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Release of eIF4E Cellular response to heat stress S6K1-mediated signalling mTORC1-mediated signalling IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS			Obesity ( 23563607)
Protein-Protein Interactions		9 interactors: CPSF1 CPSF4 CSTF3 IL7R NOL8 PAPOLA RPTOR RRAGC RRAGD	20 interactors: AKT1S1 EIF4EBP1 ICK IRS1 IRS2 MAPK1 MAPK3 MARK4 MLST8 MTOR PLD2 PRKAA1 PRKAA2 PRR5L RAP1B RHEB RPS6KA1 RPS6KB1 RRAGA RRAGB
Entrez ID		10670	57521
HPRD ID		10205	06184
Ensembl ID		ENSG00000155876	ENSG00000141564
Uniprot IDs		Q7L523	F5H7J5 Q6DKI0 Q8N122
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of TOR Signaling RNA Polyadenylation Termination Of RNA Polymerase II Transcription RNA Processing Regulation Of TOR Signaling Cellular Response To Amino Acid Stimulus DNA-templated Transcription, Termination MRNA 3'-end Processing RNA Splicing RNA 3'-end Processing Response To Amino Acid MRNA Processing Cell Growth MRNA Cleavage MRNA Metabolic Process Cellular Response To Acid Chemical Cellular Response To Nutrient Levels MRNA Polyadenylation Cellular Response To Extracellular Stimulus MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Response To Nutrient Levels Response To Extracellular Stimulus Cellular Response To Organonitrogen Compound Growth Regulation Of Autophagy Interleukin-7-mediated Signaling Pathway Modification By Virus Of Host MRNA Processing Regulation Of Cell Size Cellular Response To Starvation Negative Regulation Of T Cell Mediated Cytotoxicity Response To Starvation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Organic Substance Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Cellular Nitrogen Compound Metabolic Process Gene Expression Negative Regulation Of T Cell Mediated Immunity Modulation By Virus Of Host Process Lymph Node Development Cellular Macromolecule Biosynthetic Process Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of T Cell Differentiation In Thymus Macromolecule Biosynthetic Process	Cellular Response To Organonitrogen Compound Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Response To Peptide Hormone Enzyme Linked Receptor Protein Signaling Pathway Regulation Of TOR Signaling Response To Peptide Neurotrophin Signaling Pathway Cellular Response To Hormone Stimulus Intracellular Signal Transduction Cell Communication Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Response To Heat Response To Hormone Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Response To Stress Cellular Response To Fibroblast Growth Factor Stimulus Response To Temperature Stimulus Response To Fibroblast Growth Factor Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Heat Fc-epsilon Receptor Signaling Pathway Response To Stimulus TOR Signaling Signaling Positive Regulation Of Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of Intracellular Signal Transduction Cellular Response To Heat Positive Regulation Of TOR Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Tagcloud ?			ablation balanced cns complexes contributions delicately functionally hypomyelination integrates lipogenesis lipogenic minor mtor mtorc1 mtorc2 myelin myelination oligodendrocyte oligodendrocytes overactivation overtones practical rapamycin reliant rictor sclerosis tsc1 tuberous
Tagcloud (Difference) ?			ablation balanced cns complexes contributions delicately functionally hypomyelination integrates lipogenesis lipogenic minor mtor mtorc1 mtorc2 myelin myelination oligodendrocyte oligodendrocytes overactivation overtones practical rapamycin reliant rictor sclerosis tsc1 tuberous
Tagcloud (Intersection) ?