CXCL13 and CXCR3

Number of citations of the paper that reports this interaction (PMID 11554781)
6

Data Source:
HPRD (in vitro, in vivo)

		CXCL13	CXCR3
Gene Name		chemokine (C-X-C motif) ligand 13	chemokine (C-X-C motif) receptor 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Chemokine Activity Heparin Binding Fibroblast Growth Factor Binding CXCR5 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Protein Heterodimerization Activity Receptor Agonist Activity CXCR3 Chemokine Receptor Binding	Receptor Activity Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-X-C Chemokine Binding
	Biological Process	Germinal Center Formation Lymphocyte Chemotaxis Across High Endothelial Venule Chronic Inflammatory Response Regulation Of Humoral Immune Response Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of T Cell Chemotaxis Response To Lipopolysaccharide Activation Of Rap GTPase Activity Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin B Cell Chemotaxis Endothelial Cell Chemotaxis To Fibroblast Growth Factor B Cell Chemotaxis Across High Endothelial Venule Regulation Of Cell Proliferation Defense Response To Bacterium Regulation Of Angiogenesis Lymph Node Development Chemokine-mediated Signaling Pathway Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Regulation Of Leukocyte Migration Apoptotic Process Movement Of Cell Or Subcellular Component Chemotaxis Inflammatory Response Cell Adhesion Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation T Cell Chemotaxis Negative Regulation Of Angiogenesis Calcium-mediated Signaling Positive Regulation Of CAMP Metabolic Process Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Chemokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 11 Production Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143)
Protein-Protein Interactions		8 interactors: ACKR4 CCL19 CCL21 CCR10 CXCR3 CXCR5 EEF1G FGF2	6 interactors: CXCL10 CXCL11 CXCL13 CXCL9 PF4 VCAN
Entrez ID		10563	2833
HPRD ID		05513	02936
Ensembl ID		ENSG00000156234	ENSG00000186810
Uniprot IDs		O43927 Q53X90	P49682
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Response To External Stimulus Cytosolic Calcium Ion Homeostasis Chemokine-mediated Signaling Pathway Locomotion Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Metal Ion Homeostasis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Cellular Cation Homeostasis Cellular Ion Homeostasis Regulation Of Ion Homeostasis Metal Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Regulation Of Behavior Regulation Of Dendritic Cell Dendrite Assembly Cellular Chemical Homeostasis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Ion Homeostasis Immune System Process Regulation Of Phosphatidylinositol 3-kinase Activity Immune Response Regulation Of Lipid Kinase Activity Cellular Homeostasis Response To Organic Substance Establishment Of T Cell Polarity Positive Regulation Of Locomotion Chemical Homeostasis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Leukocyte Chemotaxis Regulation Of Leukocyte Migration Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Dendritic Cell Chemotaxis Positive Regulation Of Glycoprotein Biosynthetic Process Immunological Synapse Formation Leukocyte Activation Positive Regulation Of Glycoprotein Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Prostaglandin E Cell Chemotaxis Cellular Response To Cytokine Stimulus Regulation Of Cell Migration	Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of CAMP-mediated Signaling Lymphocyte Chemotaxis Positive Regulation Of Leukocyte Migration Regulation Of CAMP-mediated Signaling Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Lymphocyte Migration Regulation Of Chemotaxis Cell Chemotaxis Regulation Of Behavior Leukocyte Migration T Cell Chemotaxis Positive Regulation Of CAMP Metabolic Process Cell Migration Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Lipopolysaccharide Positive Regulation Of Cell Migration Response To Molecule Of Bacterial Origin Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of CAMP Metabolic Process T Cell Migration Inflammatory Response Cytokine-mediated Signaling Pathway Response To Bacterium Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Locomotion Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Cytokine Response To Other Organism Response To Biotic Stimulus Response To Lipid Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Immune System Process Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Calcium Ion Transport G-protein Coupled Receptor Signaling Pathway
Tagcloud ?		aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl20 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger	allergic cc ccr1 ccr3 ccr4 ccr5 chemokine chemokines coreceptors cxcr1 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate
Tagcloud (Difference) ?		aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl20 ccl21 chemotaxis conditioned contributors converted cryosections evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger	allergic cc ccr1 ccr3 ccr4 ccr5 coreceptors cxcr1 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate
Tagcloud (Intersection) ?		chemokine chemokines