CXCR3 and PF4

Number of citations of the paper that reports this interaction (PMID 12782716)
91

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CXCR3	PF4
Gene Name		chemokine (C-X-C motif) receptor 3	platelet factor 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen
	Molecular Function	Receptor Activity Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-X-C Chemokine Binding	Chemokine Activity Heparin Binding CXCR3 Chemokine Receptor Binding
	Biological Process	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Regulation Of Leukocyte Migration Apoptotic Process Movement Of Cell Or Subcellular Component Chemotaxis Inflammatory Response Cell Adhesion Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation T Cell Chemotaxis Negative Regulation Of Angiogenesis Calcium-mediated Signaling Positive Regulation Of CAMP Metabolic Process Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Chemokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 11 Production Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis	Platelet Degranulation Positive Regulation Of Leukocyte Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Platelet Activation Leukocyte Chemotaxis Positive Regulation Of CAMP Metabolic Process Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Proliferation Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Cytolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Chemokine-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation GPCR ligand binding Metabolic disorders of biological oxidation enzymes Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall Common Pathway GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs			Drotrecogin alfa
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037)
Protein-Protein Interactions		6 interactors: CXCL10 CXCL11 CXCL13 CXCL9 PF4 VCAN	11 interactors: CCL5 CXCL12 CXCL8 CXCR3 FGF2 LDLR PROC SDC2 SRGN THBD VCAN
Entrez ID		2833	5196
HPRD ID		02936	01426
Ensembl ID		ENSG00000186810
Uniprot IDs		P49682	P02776
PDB IDs			1DN3 1F9Q 1F9R 1F9S 1PFM 1PFN 1RHP
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of CAMP-mediated Signaling Lymphocyte Chemotaxis Positive Regulation Of Leukocyte Migration Regulation Of CAMP-mediated Signaling Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Lymphocyte Migration Regulation Of Chemotaxis Cell Chemotaxis Regulation Of Behavior Leukocyte Migration T Cell Chemotaxis Positive Regulation Of CAMP Metabolic Process Cell Migration Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Lipopolysaccharide Positive Regulation Of Cell Migration Response To Molecule Of Bacterial Origin Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of CAMP Metabolic Process T Cell Migration Inflammatory Response Cytokine-mediated Signaling Pathway Response To Bacterium Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Locomotion Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Cytokine Response To Other Organism Response To Biotic Stimulus Response To Lipid Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Immune System Process Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Calcium Ion Transport G-protein Coupled Receptor Signaling Pathway	Locomotion Cell Migration Cell Motility Movement Of Cell Or Subcellular Component Positive Regulation Of Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Chemokine-mediated Signaling Pathway Regulation Of Behavior Leukocyte Migration Chemotaxis Response To External Stimulus Regulation Of Leukocyte Migration Positive Regulation Of Locomotion Cell Chemotaxis Response To Stress Glycosaminoglycan Catabolic Process Negative Regulation Of Wound Healing Positive Regulation Of Leukocyte Chemotaxis Regulation Of Cell Migration Wound Healing Regulation Of Cell Motility Regulation Of Epithelial Cell Proliferation Cellular Calcium Ion Homeostasis Regulation Of Endothelial Cell Proliferation Regulation Of Locomotion Positive Regulation Of Leukocyte Migration Calcium Ion Homeostasis Regulation Of Cellular Component Movement Response To Wounding Positive Regulation Of Calcium Ion Transport Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Immune System Process Leukocyte Chemotaxis Positive Regulation Of Cellular Component Movement Regulation Of Monocyte Chemotaxis Chemical Homeostasis Regulation Of Wound Healing Cardiovascular System Development Cellular Metal Ion Homeostasis Induction Of Positive Chemotaxis Blood Vessel Morphogenesis Positive Regulation Of T Cell Migration Response To Organic Substance Cellular Cation Homeostasis Response To Radiation Cytokine-mediated Signaling Pathway
Tagcloud ?		allergic cc ccr1 ccr3 ccr4 ccr5 chemokine chemokines coreceptors cxcr1 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate	10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4v1 phylogenetic physically ppbp primers scyb5 sdf1 separated
Tagcloud (Difference) ?		allergic cc ccr1 ccr3 ccr4 ccr5 chemokines coreceptors cxcr1 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate	10q 4q another constitutes cr divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4v1 phylogenetic physically ppbp primers scyb5 sdf1 separated
Tagcloud (Intersection) ?		chemokine cxc