GNB2L1 and SLC6A3

Number of citations of the paper that reports this interaction (PMID 15202772)
31

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		GNB2L1	SLC6A3
Gene Name		guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	solute carrier family 6 (neurotransmitter transporter), member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Small Ribosomal Subunit Dendrite Midbody Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Axon Neuronal Cell Body
	Molecular Function	Protein Kinase C Binding Receptor Binding Protein Binding Ion Channel Inhibitor Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Phosphatase Binding Protein Tyrosine Kinase Inhibitor Activity Receptor Tyrosine Kinase Binding Protein Complex Scaffold SH2 Domain Binding Protein Homodimerization Activity Poly(A) RNA Binding	Protease Binding Receptor Binding Dopamine Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Protein Binding Drug Binding Monoamine Transmembrane Transporter Activity Protein Complex Binding Dopamine Binding Protein N-terminus Binding
	Biological Process	Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Gastrulation Negative Regulation Of Gene Expression Viral Process Negative Regulation Of Translation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of CAMP Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Homooligomerization Regulation Of Protein Localization Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Rhythmic Process Negative Regulation Of Phagocytosis Regulation Of Cell Division Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Establishment Of Cell Polarity Positive Regulation Of Gastrulation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Neurotransmitter Transport Synaptic Transmission Aging Lactation Sensory Perception Of Smell Locomotory Behavior Response To Iron Ion Monoamine Transport Dopamine Transport Adenohypophysis Development Response To Nicotine Positive Regulation Of Multicellular Organism Growth Regulation Of Dopamine Metabolic Process Neurotransmitter Biosynthetic Process Response To Cocaine Dopamine Biosynthetic Process Dopamine Catabolic Process Response To Drug Response To Ethanol Response To CAMP Transmembrane Transport Prepulse Inhibition Ammonium Transmembrane Transport Cation Transmembrane Transport
Pathways			Na+/Cl- dependent neurotransmitter transporters Dopamine clearance from the synaptic cleft Neurotransmitter Clearance In The Synaptic Cleft Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds SLC-mediated transmembrane transport Transmission across Chemical Synapses
Drugs			Amphetamine Phentermine Benzatropine Venlafaxine Methylphenidate Duloxetine Mazindol Procaine Trimipramine Modafinil Phenmetrazine Pseudoephedrine Benzphetamine Cocaine Diethylpropion Dopamine Sertraline Sibutramine Chlorpheniramine Diphenylpyraline Nefazodone Bupropion Chloroprocaine Escitalopram Lisdexamfetamine Ephedra MMDA 3,4-Methylenedioxymethamphetamine Fencamfamine 4-Methoxyamphetamine Dextroamphetamine Methamphetamine Nomifensine Dexmethylphenidate
Diseases
GWAS
Protein-Protein Interactions		86 interactors: ADH1B ADRB2 AGTRAP AR AURKB BCL2L11 CCNA1 CDKN1A CHERP CSF2RB DDX19B DGCR14 DNM1 DYNLL1 EIF6 EPOR FBXW7 FYN GABRB3 GNB1 GOLM1 GRAP2 GRIN2B HABP4 HIF1A HNRNPH2 IFNAR1 IFNAR2 IFNR IGF1R IK IL2RB IL4R IL7R INSR ITGB1 ITGB2 ITGB5 ITGB7 JAK1 LARP4B LRP12 MAPK6 MKRN2 NFATC1 NR3C1 NSMAF PABPC1 PDE4D PLCG1 PLEC PRKAB2 PRKCA PRKCB PRKCD PRKCE PRKD1 PRPF31 PTN PTOV1 PTPRM RASA1 RASA3 RB1 RHOA SAT1 SLC27A6 SLC6A3 SRC SREK1 ST7 STAT1 STAT3 SUMO4 SYT1 TARDBP TBXA2R TCEB1 TCEB2 TNFRSF1A TP63 TP73 TSC22D4 TUBB TYK2 WDR83	8 interactors: DRD2 GNB2L1 NEDD4 PICK1 SNCA SNTA1 STX1A TGFB1I1
Entrez ID		10399	6531
HPRD ID		01503	00543
Ensembl ID		ENSG00000204628	ENSG00000142319
Uniprot IDs		E9KL35 P63244	Q01959
PDB IDs		3J3A 4AOW
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Cellular Response To Stimulus Signal Transduction Response To Stimulus Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Intracellular Signal Transduction Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Response To External Stimulus Defense Response Viral Process Response To Stress Immune System Process Regulation Of Immune Response Regulation Of Body Fluid Levels Regulation Of Cell Proliferation Regulation Of Immune System Process Response To Abiotic Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Signal Transduction Regulation Of Cellular Localization Response To Cytokine Regulation Of Cell Death Regulation Of Cellular Process Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Platelet Activation Innate Immune Response Immune Response Regulation Of Phosphorylation Blood Coagulation Regulation Of Apoptotic Process Hemostasis Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Cycle Positive Regulation Of Transport Peptidyl-tyrosine Autophosphorylation Cellular Process Neurotrophin TRK Receptor Signaling Pathway Developmental Process Regulation Of Angiogenesis Positive Regulation Of Cellular Metabolic Process	Regulation Of Vesicle-mediated Transport Synapse Organization Regulation Of Cellular Component Organization Regulation Of Endocytosis Receptor Internalization Negative Regulation Of Signaling Negative Regulation Of Synaptic Transmission Regulation Of Sodium Ion Transport Regulation Of Membrane Potential Positive Regulation Of Transport Regulation Of Synaptic Transmission Receptor Metabolic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Ion Transport Positive Regulation Of Endocytosis Regulation Of Signaling Negative Regulation Of Transport Positive Regulation Of Synaptic Transmission Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Cellular Localization Regulation Of Neurotransmitter Uptake Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Positive Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Receptor Internalization Regulation Of Dopamine Secretion Regulation Of Ion Homeostasis Regulation Of Synaptic Plasticity Synaptic Transmission Regulation Of Ion Transport Monoamine Transport Dopamine Metabolic Process Regulation Of Response To Reactive Oxygen Species Vesicle-mediated Transport Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Receptor Internalization Response To Iron Ion Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Transporter Activity Regulation Of Synaptic Vesicle Transport Catecholamine Metabolic Process Regulation Of Cellular Response To Oxidative Stress Response To Cocaine Cell-cell Signaling Positive Regulation Of Secretion Neuromuscular Junction Development
Tagcloud ?		aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h	adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic htr2a latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic trajectories variations
Tagcloud (Difference) ?		aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h	adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic htr2a latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic trajectories variations
Tagcloud (Intersection) ?