SLC6A3 and PICK1

Number of citations of the paper that reports this interaction (PMID 11343649)
57

Data Source:
HPRD (in vivo, two hybrid)

		SLC6A3	PICK1
Gene Name		solute carrier family 6 (neurotransmitter transporter), member 3	protein interacting with PRKCA 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Axon Neuronal Cell Body	Cytoplasm Mitochondrion Golgi Apparatus Cytoskeleton Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane Neuron Projection Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Postsynaptic Density
	Molecular Function	Protease Binding Receptor Binding Dopamine Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Protein Binding Drug Binding Monoamine Transmembrane Transporter Activity Protein Complex Binding Dopamine Binding Protein N-terminus Binding	G-protein Coupled Receptor Binding Protein Kinase C Binding Receptor Binding Protein Binding Protein C-terminus Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Neurotransmitter Transport Synaptic Transmission Aging Lactation Sensory Perception Of Smell Locomotory Behavior Response To Iron Ion Monoamine Transport Dopamine Transport Adenohypophysis Development Response To Nicotine Positive Regulation Of Multicellular Organism Growth Regulation Of Dopamine Metabolic Process Neurotransmitter Biosynthetic Process Response To Cocaine Dopamine Biosynthetic Process Dopamine Catabolic Process Response To Drug Response To Ethanol Response To CAMP Transmembrane Transport Prepulse Inhibition Ammonium Transmembrane Transport Cation Transmembrane Transport	Positive Regulation Of Receptor Internalization Protein Phosphorylation Protein Targeting Retrograde Vesicle-mediated Transport, Golgi To ER Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Monoamine Transport Glial Cell Development Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Long Term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance
Pathways		Na+/Cl- dependent neurotransmitter transporters Dopamine clearance from the synaptic cleft Neurotransmitter Clearance In The Synaptic Cleft Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds SLC-mediated transmembrane transport Transmission across Chemical Synapses	Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs		Amphetamine Phentermine Benzatropine Venlafaxine Methylphenidate Duloxetine Mazindol Procaine Trimipramine Modafinil Phenmetrazine Pseudoephedrine Benzphetamine Cocaine Diethylpropion Dopamine Sertraline Sibutramine Chlorpheniramine Diphenylpyraline Nefazodone Bupropion Chloroprocaine Escitalopram Lisdexamfetamine Ephedra MMDA 3,4-Methylenedioxymethamphetamine Fencamfamine 4-Methoxyamphetamine Dextroamphetamine Methamphetamine Nomifensine Dexmethylphenidate
Diseases
GWAS
Protein-Protein Interactions		8 interactors: DRD2 GNB2L1 NEDD4 PICK1 SNCA SNTA1 STX1A TGFB1I1	47 interactors: APTX AQP1 ARF1 ARF3 ASIC1 ASIC2 ATXN1L ATXN3 ATXN7 ATXN7L3 BTG2 CIC COIL CTNNB1 EFNB1 EFNB2 EHD2 EPHB2 ERBB2 ERBB2IP F11R FXN GFI1 GFI1B GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIP1 GRM3 GRM7 JAM3 LRP2BP MLLT4 PARK2 PRKCA PRKCG PRLHR PVRL2 PVRL4 SACS SLC6A3 UBQLN4 USP7
Entrez ID		6531	9463
HPRD ID		00543	16176
Ensembl ID		ENSG00000142319	ENSG00000100151
Uniprot IDs		Q01959	B3KS52 Q9NRD5
PDB IDs			2GZV
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Synapse Organization Regulation Of Cellular Component Organization Regulation Of Endocytosis Receptor Internalization Negative Regulation Of Signaling Negative Regulation Of Synaptic Transmission Regulation Of Sodium Ion Transport Regulation Of Membrane Potential Positive Regulation Of Transport Regulation Of Synaptic Transmission Receptor Metabolic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Ion Transport Positive Regulation Of Endocytosis Regulation Of Signaling Negative Regulation Of Transport Positive Regulation Of Synaptic Transmission Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Cellular Localization Regulation Of Neurotransmitter Uptake Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Positive Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Receptor Internalization Regulation Of Dopamine Secretion Regulation Of Ion Homeostasis Regulation Of Synaptic Plasticity Synaptic Transmission Regulation Of Ion Transport Monoamine Transport Dopamine Metabolic Process Regulation Of Response To Reactive Oxygen Species Vesicle-mediated Transport Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Receptor Internalization Response To Iron Ion Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Transporter Activity Regulation Of Synaptic Vesicle Transport Catecholamine Metabolic Process Regulation Of Cellular Response To Oxidative Stress Response To Cocaine Cell-cell Signaling Positive Regulation Of Secretion Neuromuscular Junction Development	Cell-cell Signaling Synaptic Transmission Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Cellular Response To Stimulus Regulation Of Cellular Process Response To Stimulus Signaling Cell Communication Behavior Regulation Of Synaptic Transmission Single-organism Behavior Neurological System Process Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Signal Transduction Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Anatomical Structure Development Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Nervous System Development Negative Regulation Of Synaptic Transmission, Glutamatergic Cell Junction Assembly Developmental Process Ion Transport Cell-cell Junction Organization Ion Transmembrane Transport G-protein Coupled Glutamate Receptor Signaling Pathway Histone Deubiquitination Learning Or Memory Negative Regulation Of Adenylate Cyclase Activity Multicellular Organismal Development Regulation Of Body Fluid Levels Negative Regulation Of Lyase Activity Establishment Of Endothelial Barrier Cognition Response To External Stimulus System Development Regulation Of Signaling Adherens Junction Organization Multicellular Organismal Response To Stress Negative Regulation Of CAMP Biosynthetic Process Cellular Process Negative Regulation Of CAMP Metabolic Process Sensory Perception Of Sour Taste Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Death Negative Regulation Of Programmed Cell Death
Tagcloud ?		adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic htr2a latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic trajectories variations	altering ampa calsyntenin clarified confirming coordinated deprivation elicited excitotoxic glua1 glun2a glun2b glun3a grip1 hippocampal insults ionotropic ischemia ogd profound proteome repression sapap2 snap submitted synaptic tarpgamma3 transcriptome vulnerability
Tagcloud (Difference) ?		adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic htr2a latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic trajectories variations	altering ampa calsyntenin clarified confirming coordinated deprivation elicited excitotoxic glua1 glun2a glun2b glun3a grip1 hippocampal insults ionotropic ischemia ogd profound proteome repression sapap2 snap submitted synaptic tarpgamma3 transcriptome vulnerability
Tagcloud (Intersection) ?