DLC1 and RPS6KA1

Number of citations of the paper that reports this interaction (PMID 16338927)
8

Data Source:
BioGRID (enzymatic study)

		DLC1	RPS6KA1
Gene Name		DLC1 Rho GTPase activating protein	ribosomal protein S6 kinase, 90kDa, polypeptide 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Caveola Focal Adhesion	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol
	Molecular Function	Rho GTPase Activator Activity Protein Binding Lipid Binding Rac GTPase Activator Activity SH2 Domain Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Neural Tube Closure Heart Morphogenesis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Hindbrain Morphogenesis Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Forebrain Development Positive Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Dephosphorylation Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Execution Phase Of Apoptosis	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Cell Cycle Signal Transduction Synaptic Transmission Axon Guidance Positive Regulation Of Cell Growth Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Positive Regulation Of Hepatic Stellate Cell Activation
Pathways		Rho GTPase cycle Signaling by Rho GTPases	Signaling by GPCR CREB phosphorylation Axon guidance Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence CREB phosphorylation L1CAM interactions Recycling pathway of L1 CREB phosphorylation through the activation of Ras Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK RSK activation Activation of NMDA receptor upon glutamate binding and postsynaptic events MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ERK/MAPK targets Post NMDA receptor activation events Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Senescence-Associated Secretory Phenotype (SASP) NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Transmission across Chemical Synapses Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Bipolar disorder ( 22688191) Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: AKT1 RPS6KA1	51 interactors: ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DLC1 EEF1D EEF2K ESR1 ETV1 FGFR1 FOS GBP2 GMFB GRB2 GSK3B L1CAM MAGI1 MAPK1 MAPK3 MAPT METTL1 MITF MPP1 MTOR MXD1 NFKBIA NR4A1 NR4A2 NR4A3 PDCD4 PDPK1 PHAX POLDIP3 PPM1G PPP1R3A RPTOR SRF SRSF5 SYK TOB2 TSC2 TTK VCP YBX1 YWHAB
Entrez ID		10395	6195
HPRD ID		05035	03402
Ensembl ID		ENSG00000164741	ENSG00000117676
Uniprot IDs		A8K119 E9PDZ8 Q96QB1	E9PRI4 Q15418
PDB IDs		2DKY 2GYT 2KAP 2LOZ 3KUQ	2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Growth Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Glycogen Cell Differentiation Involved In Embryonic Placenta Development Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Growth Neurotrophin Signaling Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Translation Negative Regulation Of Peptidase Activity Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell Growth Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Posttranscriptional Regulation Of Gene Expression Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Response To UV-A Activation-induced Cell Death Of T Cells Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Growth Regulation Of Proteolysis Negative Regulation Of Fatty Acid Oxidation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Catalytic Activity Nitric Oxide Biosynthetic Process Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Size Regulation Of Translation In Response To Stress Positive Regulation Of Cell Differentiation Negative Regulation Of Release Of Cytochrome C From Mitochondria Spongiotrophoblast Layer Development Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process T Cell Apoptotic Process Regulation Of Fatty Acid Beta-oxidation	Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Innate Immune Response Response To Fibroblast Growth Factor Response To Organonitrogen Compound Cellular Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Immune Response Response To Growth Factor Regulation Of Immune Response Defense Response Positive Regulation Of Cellular Biosynthetic Process Response To Abiotic Stimulus Phosphatidylinositol-mediated Signaling Response To External Stimulus Cellular Response To Hormone Stimulus Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Insulin Receptor Signaling Pathway Response To Peptide Cellular Response To Heat Immune System Process Cell Communication Regulation Of Phosphorylation Response To Temperature Stimulus Response To Peptide Hormone Positive Regulation Of Transcription, DNA-templated Signal Transduction Signaling Positive Regulation Of Gene Expression Response To Stress Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Chemotaxis Cellular Response To Insulin Stimulus
Tagcloud ?		bc bcl2l2 bctis breakthrough ccna1 comprehending ctsd deregulated deregulations diseasespecific fivefold gabrp gsn her2positive hnepi insignificant itga6 klk5 microdissected ngfb ontological profilebased rpl27 scbg2a1 scgb1d2 serpinb5 stc2 taxonomy tumoradjacent	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 tlr8 tradition
Tagcloud (Difference) ?		bc bcl2l2 bctis breakthrough ccna1 comprehending ctsd deregulated deregulations diseasespecific fivefold gabrp gsn her2positive hnepi insignificant itga6 klk5 microdissected ngfb ontological profilebased rpl27 scbg2a1 scgb1d2 serpinb5 stc2 taxonomy tumoradjacent	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 tlr8 tradition
Tagcloud (Intersection) ?