RPS6KA1 and NR4A3

Number of citations of the paper that reports this interaction (PMID 16223362)
14

Data Source:
HPRD (in vivo)

		RPS6KA1	NR4A3
Gene Name		ribosomal protein S6 kinase, 90kDa, polypeptide 1	nuclear receptor subfamily 4, group A, member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Steroid Hormone Receptor Activity Thyroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Cell Cycle Signal Transduction Synaptic Transmission Axon Guidance Positive Regulation Of Cell Growth Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Positive Regulation Of Hepatic Stellate Cell Activation	Mesoderm Formation Transcription Initiation From RNA Polymerase II Promoter Axon Guidance Biological_process Gene Expression Hippocampus Development Intracellular Receptor Signaling Pathway Adult Behavior Organ Regeneration Response To Hydrogen Peroxide Steroid Hormone Mediated Signaling Pathway Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Semicircular Canal Morphogenesis Neuromuscular Process Controlling Balance Vestibular Reflex Positive Regulation Of Leukocyte Apoptotic Process
Pathways		Signaling by GPCR CREB phosphorylation Axon guidance Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence CREB phosphorylation L1CAM interactions Recycling pathway of L1 CREB phosphorylation through the activation of Ras Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK RSK activation Activation of NMDA receptor upon glutamate binding and postsynaptic events MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ERK/MAPK targets Post NMDA receptor activation events Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Senescence-Associated Secretory Phenotype (SASP) NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Transmission across Chemical Synapses Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS			Dental caries ( 23064961)
Protein-Protein Interactions		51 interactors: ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DLC1 EEF1D EEF2K ESR1 ETV1 FGFR1 FOS GBP2 GMFB GRB2 GSK3B L1CAM MAGI1 MAPK1 MAPK3 MAPT METTL1 MITF MPP1 MTOR MXD1 NFKBIA NR4A1 NR4A2 NR4A3 PDCD4 PDPK1 PHAX POLDIP3 PPM1G PPP1R3A RPTOR SRF SRSF5 SYK TOB2 TSC2 TTK VCP YBX1 YWHAB	5 interactors: COPS5 RPS6KA1 SIX3 TRIM28 VHL
Entrez ID		6195	8013
HPRD ID		03402	02766
Ensembl ID		ENSG00000117676	ENSG00000119508
Uniprot IDs		E9PRI4 Q15418	Q92570
PDB IDs		2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Innate Immune Response Response To Fibroblast Growth Factor Response To Organonitrogen Compound Cellular Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Immune Response Response To Growth Factor Regulation Of Immune Response Defense Response Positive Regulation Of Cellular Biosynthetic Process Response To Abiotic Stimulus Phosphatidylinositol-mediated Signaling Response To External Stimulus Cellular Response To Hormone Stimulus Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Insulin Receptor Signaling Pathway Response To Peptide Cellular Response To Heat Immune System Process Cell Communication Regulation Of Phosphorylation Response To Temperature Stimulus Response To Peptide Hormone Positive Regulation Of Transcription, DNA-templated Signal Transduction Signaling Positive Regulation Of Gene Expression Response To Stress Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Chemotaxis Cellular Response To Insulin Stimulus	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Neuroblast Migration Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA Demethylation Optic Vesicle Morphogenesis Positive Regulation Of Hepatic Stellate Cell Activation Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Anatomical Structure Morphogenesis Regulation Of Neural Retina Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Lens Fiber Cell Apoptotic Process Neuroblast Differentiation Exosomal Secretion Cell Morphogenesis Negative Regulation Of Transcription, DNA-templated Proximal/distal Axis Specification Convergent Extension Involved In Axis Elongation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Genetic Imprinting DNA Methylation Involved In Embryo Development Cellular Protein Modification Process Negative Regulation Of Gene Expression Stem Cell Differentiation Negative Regulation Of Biosynthetic Process Forebrain Anterior/posterior Pattern Specification Cullin Deneddylation Forebrain Dorsal/ventral Pattern Formation Lens Induction In Camera-type Eye Protein Deneddylation Cellular Response To Stress Regulation Of Cell Differentiation Convergent Extension Telencephalon Regionalization Negative Regulation Of Viral Release From Host Cell Regulation Of Metabolic Process
Tagcloud ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 tlr8 tradition	annotation ccaat cebpd crosstalk cytoscape degs dissect downloaded encyclopedia fbj fosb gse14245 gse21654 gse32676 hub klf5 kruppel kyoto logarithm logfc omnibus ontology pentraxin ppi ptx3 sfn stratifin tfs trasfac
Tagcloud (Difference) ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 tlr8 tradition	annotation ccaat cebpd crosstalk cytoscape degs dissect downloaded encyclopedia fbj fosb gse14245 gse21654 gse32676 hub klf5 kruppel kyoto logarithm logfc omnibus ontology pentraxin ppi ptx3 sfn stratifin tfs trasfac
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