DLC1

Gene Name		DLC1 Rho GTPase activating protein
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Caveola Focal Adhesion
	Molecular Function	Rho GTPase Activator Activity Protein Binding Lipid Binding Rac GTPase Activator Activity SH2 Domain Binding
	Biological Process	Neural Tube Closure Heart Morphogenesis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Hindbrain Morphogenesis Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Forebrain Development Positive Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Dephosphorylation Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Execution Phase Of Apoptosis
Pathways		Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS		Bipolar disorder ( 22688191) Obesity-related traits ( 23251661)
Protein-protein Interactions		2 interactors: AKT1 RPS6KA1
Entrez ID		10395
HPRD ID		05035
Ensembl ID		ENSG00000164741
Uniprot IDs		A8K119 E9PDZ8 Q96QB1
PDB IDs		2DKY 2GYT 2KAP 2LOZ 3KUQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Growth Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Glycogen Cell Differentiation Involved In Embryonic Placenta Development Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Growth Neurotrophin Signaling Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Translation Negative Regulation Of Peptidase Activity Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell Growth Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Posttranscriptional Regulation Of Gene Expression Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Response To UV-A Activation-induced Cell Death Of T Cells Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Growth Regulation Of Proteolysis Negative Regulation Of Fatty Acid Oxidation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Catalytic Activity Nitric Oxide Biosynthetic Process Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Size Regulation Of Translation In Response To Stress Positive Regulation Of Cell Differentiation Negative Regulation Of Release Of Cytochrome C From Mitochondria Spongiotrophoblast Layer Development Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process T Cell Apoptotic Process Regulation Of Fatty Acid Beta-oxidation
Tagcloud ?		bc bcl2l2 bctis breakthrough ccna1 comprehending ctsd deregulated deregulations diseasespecific fivefold gabrp gsn her2positive hnepi insignificant itga6 klk5 microdissected ngfb ontological profilebased rpl27 scbg2a1 scgb1d2 serpinb5 stc2 taxonomy tumoradjacent