TNK2 and ARSE

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		TNK2	ARSE
Gene Name		tyrosine kinase, non-receptor, 2	arylsulfatase E (chondrodysplasia punctata 1)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endosome Plasma Membrane Coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Grb2-EGFR Complex	Endoplasmic Reticulum Lumen Golgi Stack Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Metal Ion Binding WW Domain Binding Hormone Receptor Binding	Arylsulfatase Activity Metal Ion Binding
	Biological Process	Endocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase Mediated Signal Transduction Phosphorylation Cell Migration Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-mediated Endocytosis	Skeletal System Development Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process
Pathways			Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism Post-translational protein modification The activation of arylsulfatases Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs		Adenosine triphosphate Debromohymenialdisine
Diseases
GWAS			Height ( 21998595 22021425)
Protein-Protein Interactions		41 interactors: AQP1 AR ARSE BAG3 CDC42 CLTC CSPG4 CTTN EGFR FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NL NPHP1 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SIAH1 SMURF1 SNX9 SRC SRSF5 VTI1B WAS WWOX WWP2 YES1	4 interactors: COQ6 NDN TMEM259 TNK2
Entrez ID		10188	415
HPRD ID		06104	02171
Ensembl ID		ENSG00000061938	ENSG00000157399
Uniprot IDs		B3KXJ4 C9J1X3 Q07912	F5GYY5 F5H324 P51690
PDB IDs		1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Phagocytosis Endocytosis Fc Receptor Signaling Pathway Signaling Positive Regulation Of Signal Transduction Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Developmental Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Neuron Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Apoptotic Process Anatomical Structure Development Neuron Projection Development Locomotion Immune Response-regulating Signaling Pathway Cell Migration Regulation Of Cell Death Leukocyte Migration Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Neuron Differentiation T Cell Costimulation Cell Projection Organization Neurogenesis Axon Guidance Nervous System Development Vesicle-mediated Transport Positive Regulation Of Protein Complex Assembly Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component System Development Positive Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Generation Of Neurons Neuron Projection Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Multicellular Organismal Development Positive Regulation Of Immune Response Negative Regulation Of Signal Transduction	Regulation Of Clathrin-mediated Endocytosis Respiratory System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ubiquinone Biosynthetic Process Secondary Metabolite Biosynthetic Process Ubiquinone Metabolic Process Axonal Fasciculation Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Genetic Imprinting Neuron Recognition Quinone Metabolic Process Peptidyl-tyrosine Autophosphorylation
Tagcloud ?		ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein
Tagcloud (Difference) ?		ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein
Tagcloud (Intersection) ?