TNK2 and SNX9

Number of citations of the paper that reports this interaction (PMID 11799118)
23

Data Source:
HPRD (in vivo, in vitro)

		TNK2	SNX9
Gene Name		tyrosine kinase, non-receptor, 2	sorting nexin 9
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endosome Plasma Membrane Coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Grb2-EGFR Complex	Ruffle Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Metal Ion Binding WW Domain Binding Hormone Receptor Binding	Protein Binding 1-phosphatidylinositol Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol Binding Protein Homodimerization Activity Arp2/3 Complex Binding
	Biological Process	Endocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase Mediated Signal Transduction Phosphorylation Cell Migration Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-mediated Endocytosis	Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Mitotic Nuclear Division Vesicle Organization Endosomal Transport Positive Regulation Of Protein Oligomerization Cleavage Furrow Formation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Lipid Tube Assembly Membrane Tubulation
Pathways			Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs		Adenosine triphosphate Debromohymenialdisine
Diseases
GWAS
Protein-Protein Interactions		41 interactors: AQP1 AR ARSE BAG3 CDC42 CLTC CSPG4 CTTN EGFR FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NL NPHP1 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SIAH1 SMURF1 SNX9 SRC SRSF5 VTI1B WAS WWOX WWP2 YES1	15 interactors: ADAM15 ADAM9 CLTC DNM1 DNM2 FASLG ITCH KHDRBS1 MPHOSPH6 MPP6 PAK2 SOS1 SOS2 TNK2 WASL
Entrez ID		10188	51429
HPRD ID		06104	12072
Ensembl ID		ENSG00000061938	ENSG00000130340
Uniprot IDs		B3KXJ4 C9J1X3 Q07912	Q9Y5X1
PDB IDs		1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7	2RAI 2RAJ 2RAK 3DYT 3DYU 3LGE
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Phagocytosis Endocytosis Fc Receptor Signaling Pathway Signaling Positive Regulation Of Signal Transduction Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Developmental Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Neuron Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Apoptotic Process Anatomical Structure Development Neuron Projection Development Locomotion Immune Response-regulating Signaling Pathway Cell Migration Regulation Of Cell Death Leukocyte Migration Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Neuron Differentiation T Cell Costimulation Cell Projection Organization Neurogenesis Axon Guidance Nervous System Development Vesicle-mediated Transport Positive Regulation Of Protein Complex Assembly Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component System Development Positive Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Generation Of Neurons Neuron Projection Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Multicellular Organismal Development Positive Regulation Of Immune Response Negative Regulation Of Signal Transduction	Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Membrane Tubulation Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Internalization Cell Morphogenesis Involved In Differentiation Axon Guidance Signal Transduction Cell Development Response To External Stimulus Locomotion Innate Immune Response Immune Response Neuron Projection Development Signaling Cell Projection Morphogenesis Cell Communication Cell Part Morphogenesis Axonogenesis Neuron Development Receptor Metabolic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Chemotaxis Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Cell Death Regulation Of Catalytic Activity Endocytosis Anatomical Structure Morphogenesis Neuron Differentiation Cellular Response To Stimulus Cell Projection Organization Developmental Process Positive Regulation Of Metabolic Process Maturation Of 5.8S RRNA Positive Regulation Of Protein Metabolic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Mitotic Cell Cycle Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of ERBB Signaling Pathway Defense Response Nitric Oxide Metabolic Process Regulation Of Apoptotic Process
Tagcloud ?		ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein	actin apical asap1 associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens syndapin unlikely wh2
Tagcloud (Difference) ?		ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein	actin apical asap1 associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens syndapin unlikely wh2
Tagcloud (Intersection) ?