HIPK3 and MTMR4

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HIPK3	MTMR4
Gene Name		homeodomain interacting protein kinase 3	myotubularin related protein 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm PML Body	Extracellular Space Cytosol Early Endosome Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity	Protein Dephosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Response To Denervation Involved In Regulation Of Muscle Adaptation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Small Molecule Metabolic Process
Pathways			Loss of Function of TGFBR2 in Cancer Synthesis of PIPs at the early endosome membrane TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Metabolism of lipids and lipoproteins Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Synthesis of PIPs at the late endosome membrane Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Phospholipid metabolism SMAD4 MH2 Domain Mutants in Cancer PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: AR ARRB2 C1QA CREB1 DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX	2 interactors: HIPK3 NEDD4
Entrez ID		10114	9110
HPRD ID		05111	11945
Ensembl ID		ENSG00000110422	ENSG00000108389
Uniprot IDs		Q9H422	Q9NYA4
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Signal Transduction Regulation Of RNA Metabolic Process RNA Metabolic Process Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Cellular Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Component Assembly Negative Regulation Of Gene Expression Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Motor Neuron Apoptotic Process Transcription, DNA-templated Cellular Aromatic Compound Metabolic Process Protein Oligomerization RNA Biosynthetic Process Response To Organic Substance Cellular Response To Organic Substance RNA Splicing Regulation Of Extrinsic Apoptotic Signaling Pathway Viral Process Regulation Of RNA Splicing Cellular Metabolic Process RNA Processing Cellular Response To Growth Factor Stimulus Androgen Receptor Signaling Pathway Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signaling Necroptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Transmission Of Virus Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Development Involved In Symbiotic Interaction Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Glucocorticoid Receptor Signaling Pathway Negative Regulation Of JUN Kinase Activity Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Lysosome MRNA Transcription Receptor Catabolic Process Protein Targeting To Vacuole Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Vacuole Negative Regulation Of Signal Transduction Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Signaling Negative Regulation Of JNK Cascade Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Stress-activated MAPK Cascade Endocardial Cushion Development Regulation Of Potassium Ion Transmembrane Transport Protein Monoubiquitination Receptor Internalization Lysosomal Transport Peptidyl-threonine Phosphorylation Neuromuscular Junction Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV Regulation Of Potassium Ion Transport Outflow Tract Morphogenesis Regulation Of Sodium Ion Transport Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Intracellular Signal Transduction Regulation Of Dendrite Morphogenesis Intracellular Steroid Hormone Receptor Signaling Pathway Vacuolar Transport Receptor Metabolic Process Regulation Of JUN Kinase Activity Negative Regulation Of MAP Kinase Activity Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Cellular Response To Light Stimulus Negative Regulation Of Cellular Metabolic Process
Tagcloud ?			accompanies atrophy confer consequence cre denervated denervation fgfr1 fibres flox fourteen gastrocnemius immobility inactivity ligases littermates moieties muscle myo nedd4 pathophysiologic proteolysis skeletal tibial transection twitch ubiquitin unloading weights
Tagcloud (Difference) ?			accompanies atrophy confer consequence cre denervated denervation fgfr1 fibres flox fourteen gastrocnemius immobility inactivity ligases littermates moieties muscle myo nedd4 pathophysiologic proteolysis skeletal tibial transection twitch ubiquitin unloading weights
Tagcloud (Intersection) ?