MTMR4

Gene Name		myotubularin related protein 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytosol Early Endosome Membrane
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Response To Denervation Involved In Regulation Of Muscle Adaptation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Small Molecule Metabolic Process
Pathways		Loss of Function of TGFBR2 in Cancer Synthesis of PIPs at the early endosome membrane TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Metabolism of lipids and lipoproteins Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Synthesis of PIPs at the late endosome membrane Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Phospholipid metabolism SMAD4 MH2 Domain Mutants in Cancer PI Metabolism
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: HIPK3 NEDD4
Entrez ID		9110
HPRD ID		11945
Ensembl ID		ENSG00000108389
Uniprot IDs		Q9NYA4
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmission Of Virus Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Development Involved In Symbiotic Interaction Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Glucocorticoid Receptor Signaling Pathway Negative Regulation Of JUN Kinase Activity Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Lysosome MRNA Transcription Receptor Catabolic Process Protein Targeting To Vacuole Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Vacuole Negative Regulation Of Signal Transduction Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Signaling Negative Regulation Of JNK Cascade Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Stress-activated MAPK Cascade Endocardial Cushion Development Regulation Of Potassium Ion Transmembrane Transport Protein Monoubiquitination Receptor Internalization Lysosomal Transport Peptidyl-threonine Phosphorylation Neuromuscular Junction Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV Regulation Of Potassium Ion Transport Outflow Tract Morphogenesis Regulation Of Sodium Ion Transport Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Intracellular Signal Transduction Regulation Of Dendrite Morphogenesis Intracellular Steroid Hormone Receptor Signaling Pathway Vacuolar Transport Receptor Metabolic Process Regulation Of JUN Kinase Activity Negative Regulation Of MAP Kinase Activity Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Cellular Response To Light Stimulus Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		accompanies atrophy confer consequence cre denervated denervation fgfr1 fibres flox fourteen gastrocnemius immobility inactivity ligases littermates moieties muscle myo nedd4 pathophysiologic proteolysis skeletal tibial transection twitch ubiquitin unloading weights