ADA and PIAS2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ADA	PIAS2
Gene Name		adenosine deaminase	protein inhibitor of activated STAT, 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Dendrite Cytoplasm Neuronal Cell Body Cytoplasmic Membrane-bounded Vesicle Lumen	Nucleus PML Body Nuclear Speck
	Molecular Function	Purine Nucleoside Binding Adenosine Deaminase Activity Protein Binding Zinc Ion Binding	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Response To Hypoxia Histamine Secretion Trophectodermal Cell Differentiation Liver Development Placenta Development Germinal Center B Cell Differentiation Positive Regulation Of Germinal Center Formation Negative Regulation Of Leukocyte Migration Negative Regulation Of Mature B Cell Apoptotic Process Purine Nucleobase Metabolic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process Aging Purine Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Heart Rate Positive Regulation Of B Cell Proliferation Purine Nucleotide Salvage Positive Regulation Of T Cell Differentiation In Thymus Response To Vitamin E Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Activation Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Drug Response To Hydrogen Peroxide Purine-containing Compound Salvage Hypoxanthine Salvage Response To Morphine Small Molecule Metabolic Process Positive Regulation Of Smooth Muscle Contraction DATP Catabolic Process Inosine Biosynthetic Process Xanthine Biosynthetic Process Positive Regulation Of Alpha-beta T Cell Differentiation Lung Alveolus Development Peyer's Patch Development Embryonic Digestive Tract Development Negative Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Receptor Signaling Pathway Nucleobase-containing Small Molecule Metabolic Process Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Negative Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Mucus Secretion	Transcription, DNA-templated Protein Sumoylation Androgen Receptor Signaling Pathway Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways		Purine metabolism Metabolism of nucleotides Purine salvage
Drugs		Pentostatin Dipyridamole FR221647 6-Hydroxy-7,8-Dihydro Purine Nucleoside FR117016 FR236913 6-Hydroxy-1,6-Dihydro Purine Nucleoside FR233623 FR239087 FR230513 1-Deaza-Adenosine Purine Riboside (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Diseases
GWAS		Ulcerative colitis ( 23128233)
Protein-Protein Interactions		11 interactors: ADORA1 ADORA2A ADORA2B DPP4 DRD1 GRB2 NR3C1 PIAS2 SGCD TERF2IP TINF2	68 interactors: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CHMP4B CLDN2 CTBP1 DDX39B ELK1 ESR1 ESR2 FLI1 GFAP GFI1 GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 ITGB5 JUN MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 MYCN NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I ZBED1 ZBTB8A ZNF451
Entrez ID		100	9063
HPRD ID		00038	06944
Ensembl ID		ENSG00000196839	ENSG00000078043
Uniprot IDs		F5GWI4 P00813	O75928
PDB IDs		1M7M 3IAR	2ASQ 4FO9
Enriched GO Terms of Interacting Partners?		Adenosine Receptor Signaling Pathway Blood Circulation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Vasodilation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cellular Metabolic Process Protein Localization To Chromosome, Telomeric Region Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Metabolic Process Regulation Of Blood Vessel Size Regulation Of Tube Size Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Telomere Maintenance Relaxation Of Vascular Smooth Muscle Regulation Of CAMP Biosynthetic Process Relaxation Of Smooth Muscle Regulation Of CAMP Metabolic Process Maternal Behavior Positive Regulation Of Metabolic Process Negative Regulation Of Smooth Muscle Contraction Regulation Of Telomere Maintenance Negative Regulation Of Muscle Contraction Relaxation Of Muscle Temperature Homeostasis Positive Regulation Of Potassium Ion Transport Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Signaling Regulation Of Signaling Defense Response Phagocytosis Muscle System Process Response To Stress Regulation Of Smooth Muscle Contraction Cellular Defense Response Positive Regulation Of Cell Activation Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Potassium Ion Transport Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cellular Biosynthetic Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated Response To Organic Substance RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Protein Sumoylation Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Gland Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cellular Response To Lipid Macromolecule Biosynthetic Process Cellular Response To Stimulus Regulation Of Cellular Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Cell Proliferation Regulation Of Signaling Signaling
Tagcloud ?		accessibility acetylates acetyltransferases arrays assayed buffer catalytically complexed concomitantly extensively faster folded gcn5 gcn5p hat hats mgcl2 monoacetylates nacl nucleosomal nucleosome nucleosomes optimum particles polyacetylates prefers rgcn5p saga termini	293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast
Tagcloud (Difference) ?		accessibility acetylates acetyltransferases arrays assayed buffer catalytically complexed concomitantly extensively faster folded gcn5 gcn5p hat hats mgcl2 monoacetylates nacl nucleosomal nucleosome nucleosomes optimum particles polyacetylates prefers rgcn5p saga termini	293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast
Tagcloud (Intersection) ?