PIAS2 and STAT4

Number of citations of the paper that reports this interaction (PMID 12716907)
18

Data Source:
HPRD (in vivo)

		PIAS2	STAT4
Gene Name		protein inhibitor of activated STAT, 2	signal transducer and activator of transcription 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus PML Body Nuclear Speck	Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity	Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Transcription, DNA-templated Protein Sumoylation Androgen Receptor Signaling Pathway Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Androgen Receptor Signaling Pathway	Transcription, DNA-templated Protein Phosphorylation JAK-STAT Cascade Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			Behcet's disease ( 23001997 23291587) Celiac disease and Rheumatoid arthritis ( 21383967) Hepatocellular carcinoma (hepatitis B virus related) ( 23242368) Inflammatory bowel disease ( 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Primary biliary cirrhosis ( 23000144 21399635) Rheumatoid arthritis ( 20453841 20453842) Systemic lupus erythematosus ( 23273568 23053960 18204098 21408207 19165918 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-Protein Interactions		68 interactors: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CHMP4B CLDN2 CTBP1 DDX39B ELK1 ESR1 ESR2 FLI1 GFAP GFI1 GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 ITGB5 JUN MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 MYCN NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I ZBED1 ZBTB8A ZNF451	13 interactors: ADRB2 CREBBP IFNGR1 IL12RB1 IL12RB2 JUN MAP2K6 MAPK14 NMI PIAS2 STAT3 UBC ZNF467
Entrez ID		9063	6775
HPRD ID		06944	02779
Ensembl ID		ENSG00000078043	ENSG00000138378
Uniprot IDs		O75928	Q14765
PDB IDs		2ASQ 4FO9
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated Response To Organic Substance RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Protein Sumoylation Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Gland Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cellular Response To Lipid Macromolecule Biosynthetic Process Cellular Response To Stimulus Regulation Of Cellular Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Cell Proliferation Regulation Of Signaling Signaling	Defense Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Toll-like Receptor Signaling Pathway Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cell Communication RNA Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Stress Activation Of Innate Immune Response Response To Cytokine Cellular Response To Organic Substance Immune Response Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Cellular Response To Stimulus Positive Regulation Of Innate Immune Response Cytokine-mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Immune Response Intracellular Receptor Signaling Pathway Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Signaling Cell Surface Receptor Signaling Pathway MAPK Cascade Peptidyl-amino Acid Modification Positive Regulation Of Gene Expression RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast	activate activated activating autocrine bind capable clear cytotoxicity distinct enhances exerts ifn il induces leads mitogen nk occur occurs populations primarily resting similarity stat1 stat5 underlie unique uniquely
Tagcloud (Difference) ?		293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast	activate activated activating autocrine bind capable clear cytotoxicity distinct enhances exerts ifn il induces leads mitogen nk occur occurs populations primarily resting similarity stat1 stat5 underlie unique uniquely
Tagcloud (Intersection) ?