ADA and SGCD

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ADA	SGCD
Gene Name		adenosine deaminase	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Dendrite Cytoplasm Neuronal Cell Body Cytoplasmic Membrane-bounded Vesicle Lumen	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Sarcoglycan Complex Integral Component Of Membrane Sarcolemma
	Molecular Function	Purine Nucleoside Binding Adenosine Deaminase Activity Protein Binding Zinc Ion Binding
	Biological Process	Response To Hypoxia Histamine Secretion Trophectodermal Cell Differentiation Liver Development Placenta Development Germinal Center B Cell Differentiation Positive Regulation Of Germinal Center Formation Negative Regulation Of Leukocyte Migration Negative Regulation Of Mature B Cell Apoptotic Process Purine Nucleobase Metabolic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process Aging Purine Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Heart Rate Positive Regulation Of B Cell Proliferation Purine Nucleotide Salvage Positive Regulation Of T Cell Differentiation In Thymus Response To Vitamin E Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Activation Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Drug Response To Hydrogen Peroxide Purine-containing Compound Salvage Hypoxanthine Salvage Response To Morphine Small Molecule Metabolic Process Positive Regulation Of Smooth Muscle Contraction DATP Catabolic Process Inosine Biosynthetic Process Xanthine Biosynthetic Process Positive Regulation Of Alpha-beta T Cell Differentiation Lung Alveolus Development Peyer's Patch Development Embryonic Digestive Tract Development Negative Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Receptor Signaling Pathway Nucleobase-containing Small Molecule Metabolic Process Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Negative Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Mucus Secretion	Muscle Organ Development Cardiac Muscle Tissue Development Muscle Cell Development Heart Contraction Membrane Organization
Pathways		Purine metabolism Metabolism of nucleotides Purine salvage
Drugs		Pentostatin Dipyridamole FR221647 6-Hydroxy-7,8-Dihydro Purine Nucleoside FR117016 FR236913 6-Hydroxy-1,6-Dihydro Purine Nucleoside FR233623 FR239087 FR230513 1-Deaza-Adenosine Purine Riboside (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Diseases
GWAS		Ulcerative colitis ( 23128233)	Anthropometric traits ( 19260139) Multiple sclerosis (age of onset) ( 19010793) Obesity-related traits ( 23251661)
Protein-Protein Interactions		11 interactors: ADORA1 ADORA2A ADORA2B DPP4 DRD1 GRB2 NR3C1 PIAS2 SGCD TERF2IP TINF2	5 interactors: ADA FLNC SGCA SGCB SGCG
Entrez ID		100	6444
HPRD ID		00038	03246
Ensembl ID		ENSG00000196839	ENSG00000170624
Uniprot IDs		F5GWI4 P00813	Q92629
PDB IDs		1M7M 3IAR
Enriched GO Terms of Interacting Partners?		Adenosine Receptor Signaling Pathway Blood Circulation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Vasodilation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cellular Metabolic Process Protein Localization To Chromosome, Telomeric Region Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Metabolic Process Regulation Of Blood Vessel Size Regulation Of Tube Size Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Telomere Maintenance Relaxation Of Vascular Smooth Muscle Regulation Of CAMP Biosynthetic Process Relaxation Of Smooth Muscle Regulation Of CAMP Metabolic Process Maternal Behavior Positive Regulation Of Metabolic Process Negative Regulation Of Smooth Muscle Contraction Regulation Of Telomere Maintenance Negative Regulation Of Muscle Contraction Relaxation Of Muscle Temperature Homeostasis Positive Regulation Of Potassium Ion Transport Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Signaling Regulation Of Signaling Defense Response Phagocytosis Muscle System Process Response To Stress Regulation Of Smooth Muscle Contraction Cellular Defense Response Positive Regulation Of Cell Activation Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Potassium Ion Transport Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cellular Biosynthetic Process	Muscle Structure Development Muscle Cell Development Muscle Organ Development Muscle Cell Differentiation Muscle Fiber Development Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Deoxyadenosine Catabolic Process Xanthine Biosynthetic Process Anatomical Structure Development Negative Regulation Of Mucus Secretion Purine Deoxyribonucleoside Metabolic Process Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Striated Muscle Cell Development Germinal Center B Cell Differentiation Adenosine Catabolic Process DATP Catabolic Process Deoxyribonucleoside Catabolic Process Inosine Biosynthetic Process Hypoxanthine Salvage Cardiac Muscle Tissue Development Developmental Process Hypoxanthine Metabolic Process Hypoxanthine Biosynthetic Process Negative Regulation Of Mature B Cell Apoptotic Process Striated Muscle Cell Differentiation Organ Development Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Germinal Center Formation Negative Regulation Of Thymocyte Apoptotic Process Deoxyribonucleoside Triphosphate Catabolic Process DATP Metabolic Process Striated Muscle Tissue Development Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Cell-cell Adhesion Mediated By Integrin Cell Differentiation Muscle Tissue Development Regulation Of Penile Erection Vascular Smooth Muscle Cell Development Negative Regulation Of B Cell Apoptotic Process Nucleoside Triphosphate Catabolic Process Purine Ribonucleoside Catabolic Process Purine Nucleobase Biosynthetic Process Adenosine Metabolic Process Purine Nucleotide Salvage Regulation Of Germinal Center Formation Histamine Secretion Tissue Development Mature B Cell Differentiation Involved In Immune Response Positive Regulation Of T Cell Differentiation In Thymus
Tagcloud ?		accessibility acetylates acetyltransferases arrays assayed buffer catalytically complexed concomitantly extensively faster folded gcn5 gcn5p hat hats mgcl2 monoacetylates nacl nucleosomal nucleosome nucleosomes optimum particles polyacetylates prefers rgcn5p saga termini	3q13 57x10 5q33 62x10 6q21 6x10 9p21 acted airway americans beadchip chromosomes copd eqtl eqtls flanked genotypic gwas human660w illumina imputation lingo2 myh15 pdss2 quad responsiveness suggestive top trait
Tagcloud (Difference) ?		accessibility acetylates acetyltransferases arrays assayed buffer catalytically complexed concomitantly extensively faster folded gcn5 gcn5p hat hats mgcl2 monoacetylates nacl nucleosomal nucleosome nucleosomes optimum particles polyacetylates prefers rgcn5p saga termini	3q13 57x10 5q33 62x10 6q21 6x10 9p21 acted airway americans beadchip chromosomes copd eqtl eqtls flanked genotypic gwas human660w illumina imputation lingo2 myh15 pdss2 quad responsiveness suggestive top trait
Tagcloud (Intersection) ?