SGCD and FLNC

Number of citations of the paper that reports this interaction (PMID 10629222)
36

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SGCD	FLNC
Gene Name		sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	filamin C, gamma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Sarcoglycan Complex Integral Component Of Membrane Sarcolemma	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere
	Molecular Function		Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Actin Filament Binding
	Biological Process	Muscle Organ Development Cardiac Muscle Tissue Development Muscle Cell Development Heart Contraction Membrane Organization	Cell Junction Assembly Muscle Fiber Development
Pathways			Cell junction organization Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Anthropometric traits ( 19260139) Multiple sclerosis (age of onset) ( 19010793) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: ADA FLNC SGCA SGCB SGCG	29 interactors: ADRA1A ADRA1B ADRA1D CAPN3 FURIN HIPK3 INPPL1 KCND2 KY MAP2K4 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2
Entrez ID		6444	2318
HPRD ID		03246	00018
Ensembl ID		ENSG00000170624	ENSG00000128591
Uniprot IDs		Q92629	Q14315 Q59H94
PDB IDs			1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O
Enriched GO Terms of Interacting Partners?		Muscle Structure Development Muscle Cell Development Muscle Organ Development Muscle Cell Differentiation Muscle Fiber Development Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Deoxyadenosine Catabolic Process Xanthine Biosynthetic Process Anatomical Structure Development Negative Regulation Of Mucus Secretion Purine Deoxyribonucleoside Metabolic Process Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Striated Muscle Cell Development Germinal Center B Cell Differentiation Adenosine Catabolic Process DATP Catabolic Process Deoxyribonucleoside Catabolic Process Inosine Biosynthetic Process Hypoxanthine Salvage Cardiac Muscle Tissue Development Developmental Process Hypoxanthine Metabolic Process Hypoxanthine Biosynthetic Process Negative Regulation Of Mature B Cell Apoptotic Process Striated Muscle Cell Differentiation Organ Development Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Germinal Center Formation Negative Regulation Of Thymocyte Apoptotic Process Deoxyribonucleoside Triphosphate Catabolic Process DATP Metabolic Process Striated Muscle Tissue Development Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Cell-cell Adhesion Mediated By Integrin Cell Differentiation Muscle Tissue Development Regulation Of Penile Erection Vascular Smooth Muscle Cell Development Negative Regulation Of B Cell Apoptotic Process Nucleoside Triphosphate Catabolic Process Purine Ribonucleoside Catabolic Process Purine Nucleobase Biosynthetic Process Adenosine Metabolic Process Purine Nucleotide Salvage Regulation Of Germinal Center Formation Histamine Secretion Tissue Development Mature B Cell Differentiation Involved In Immune Response Positive Regulation Of T Cell Differentiation In Thymus	Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Muscle Cell Development Blood Circulation Muscle Structure Development Heart Development Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Blood Pressure Cardiovascular System Development Positive Regulation Of Systemic Arterial Blood Pressure Adrenergic Receptor Signaling Pathway Muscle Cell Differentiation Regulation Of Blood Pressure Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Cardiac Muscle Tissue Development Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Organ Development Multicellular Organismal Development Developmental Process Regulation Of The Force Of Heart Contraction Vasoconstriction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Muscle Organ Development Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Peptidyl-threonine Phosphorylation Striated Muscle Tissue Development Striated Muscle Cell Development System Development Muscle Tissue Development Regulation Of Heart Contraction Anatomical Structure Development Actin Cytoskeleton Organization Regulation Of The Force Of Heart Contraction By Chemical Signal Heart Contraction Actin Filament-based Process Myofibril Assembly Cell Development Regulation Of Blood Vessel Size Cellular Response To Carbohydrate Stimulus Regulation Of Tube Size Striated Muscle Cell Differentiation Adult Heart Development Muscle System Process Signaling Organ Growth Actomyosin Structure Organization Cell Communication Positive Regulation Of Heart Rate Peptidyl-serine Phosphorylation
Tagcloud ?		3q13 57x10 5q33 62x10 6q21 6x10 9p21 acted airway americans beadchip chromosomes copd eqtl eqtls flanked genotypic gwas human660w illumina imputation lingo2 myh15 pdss2 quad responsiveness suggestive top trait	adh6 aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Difference) ?		3q13 57x10 5q33 62x10 6q21 6x10 9p21 acted airway americans beadchip chromosomes copd eqtl eqtls flanked genotypic gwas human660w illumina imputation lingo2 myh15 pdss2 quad responsiveness suggestive top trait	adh6 aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Intersection) ?