PJA2 and KSR1

Number of citations of the paper that reports this interaction (PubMedID 27195677)
4

Data Source:
BioGRID (enzymatic study)

		PJA2	KSR1
Description		praja ring finger ubiquitin ligase 2	kinase suppressor of ras 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Cell Junction Intermediate Filament Cytoskeleton	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Ruffle Membrane Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Protein C-terminus Binding Mitogen-activated Protein Kinase Kinase Binding Metal Ion Binding Chaperone Binding Hsp90 Protein Binding 14-3-3 Protein Binding
	Biological Process	Inflammatory Response Long-term Memory Regulation Of Protein Kinase A Signaling Protein Ubiquitination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Hippo Signaling Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of P38MAPK Cascade	MAPK Cascade Activation Of MAPKKK Activity Ras Protein Signal Transduction CAMP-mediated Signaling Regulation Of Cell Proliferation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		Body mass index ( 29273807) Frontotemporal dementia with GRN mutation ( 29724592) Heel bone mineral density ( 30598549)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Systemic lupus erythematosus ( 28714469)
Interacting Genes		14 interacting genes: KSR1 MAGED1 MFHAS1 MOB1A PRKAR1A PRKAR2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J1 UBE2L6 UBE2N UBE2W	10 interacting genes: BRAP EPHB2 MAP2K1 MAPK1 MARK3 NME1 PJA2 RAF1 UBE2L3 YWHAZ
Entrez ID		9867	8844
HPRD ID		11436	18980
Ensembl ID		ENSG00000198961	ENSG00000141068
Uniprot IDs		O43164	Q8IVT5
PDB IDs			5VYK
Enriched GO Terms of Interacting Partners?
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