KSR1 and NME1

Number of citations of the paper that reports this interaction (PubMedID 12105213)
50

Data Source:
HPRD (in vitro, in vivo)

		KSR1	NME1
Description		kinase suppressor of ras 1	NME/NM23 nucleoside diphosphate kinase 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Ruffle Membrane Protein-containing Complex	Cell Nucleus Cytoplasm Mitochondrial Outer Membrane Centrosome Cytosol Intermediate Filament Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Protein C-terminus Binding Mitogen-activated Protein Kinase Kinase Binding Metal Ion Binding Chaperone Binding Hsp90 Protein Binding 14-3-3 Protein Binding	Magnesium Ion Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Single-stranded DNA Binding RNA Binding Deoxyribonuclease Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Intermediate Filament Binding Enzyme Binding Identical Protein Binding Gamma-tubulin Binding Ribosomal Small Subunit Binding
	Biological Process	MAPK Cascade Activation Of MAPKKK Activity Ras Protein Signal Transduction CAMP-mediated Signaling Regulation Of Cell Proliferation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade	Negative Regulation Of Myeloid Leukocyte Differentiation Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Metabolic Process Endocytosis Lactation Negative Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Amine Nucleobase-containing Small Molecule Interconversion Hippocampus Development Response To Testosterone Cellular Response To Drug Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epithelial Cell Proliferation Response To CAMP Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Interconversion of nucleotide di- and triphosphates
Drugs			Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate Fudp Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate 3'-Azido-3'-Deoxythymidine-5'-Diphosphate Copper
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Systemic lupus erythematosus ( 28714469)	Bipolar disorder ( 31043756) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: BRAP EPHB2 MAP2K1 MAPK1 MARK3 NME1 PJA2 RAF1 UBE2L3 YWHAZ	29 interacting genes: APEX1 AURKA CCND3 FBXO24 FXR2 GORASP2 ITGB1 KSR1 MIF NIF3L1 NME2 NME3 NME4 NTAQ1 PID1 POLR1C PRUNE1 PTEN RAC1 RORA RORB RRAD SET SMARCD1 SOX30 SREK1IP1 TERF1 TIAM1 TNPO2
Entrez ID		8844	4830
HPRD ID		18980	01131
Ensembl ID		ENSG00000141068	ENSG00000239672
Uniprot IDs		Q8IVT5	A0A384MTW7 P15531
PDB IDs		5VYK	1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4
Enriched GO Terms of Interacting Partners?
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