KSR1 and YWHAZ

Number of citations of the paper that reports this interaction (PubMedID 9858547)
58

Data Source:
HPRD (in vivo)

		KSR1	YWHAZ
Description		kinase suppressor of ras 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Ruffle Membrane Protein-containing Complex	Extracellular Space Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Focal Adhesion Vesicle Melanosome Extracellular Exosome Blood Microparticle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Protein C-terminus Binding Mitogen-activated Protein Kinase Kinase Binding Metal Ion Binding Chaperone Binding Hsp90 Protein Binding 14-3-3 Protein Binding	RNA Binding Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ion Channel Binding Cadherin Binding
	Biological Process	MAPK Cascade Activation Of MAPKKK Activity Ras Protein Signal Transduction CAMP-mediated Signaling Regulation Of Cell Proliferation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade	Angiogenesis Respiratory System Process Protein Phosphorylation Protein Targeting Signal Transduction Synaptic Target Recognition Cytokine-mediated Signaling Pathway Platelet Activation Lung Development Tube Formation Negative Regulation Of Apoptotic Process Regulation Of MRNA Stability Establishment Of Golgi Localization Membrane Organization ERK1 And ERK2 Cascade Regulation Of ERK1 And ERK2 Cascade Regulation Of Synapse Maturation Golgi Reassembly Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Systemic lupus erythematosus ( 28714469)	Adventurousness ( 30643258) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Body mass index ( 25673413) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) General risk tolerance (MTAG) ( 30643258) Interleukin-10 levels ( 22205395)
Interacting Genes		10 interacting genes: BRAP EPHB2 MAP2K1 MAPK1 MARK3 NME1 PJA2 RAF1 UBE2L3 YWHAZ	205 interacting genes: AANAT ABL1 ADAM22 ADRA2A ADRA2B ADRA2C AKAP13 AKT1 APP ARAF ARHGEF2 ATP5F1A ATXN1 BAD BCAR1 BCR BRAF BSPRY CBL CDC25A CDC25B CDC25C CDC5L CDK11B CDK16 CDK17 CDKN1B CENPJ CEP126 CEP131 CFL1 CGNL1 CLIC4 COP1 CRTC2 CSF2RB CSNK1A1 CSNK1D DFFA DISC1 EFNB3 EGFR EIF3A ENO1 EP300 EPB41L1 EPB41L2 EPB41L3 EXO1 FAM13B FHOD1 FOXO1 FOXO3 FOXO4 GABARAPL2 GABBR1 GCH1 GP1BA GP1BB GP5 GSK3B H3C1 HDAC4 HDAC6 HDAC9 HIVEP2 HMGN1 HSPA1A HSPA1B HSPB1 IGF1R IL9R ING1 INPP5A IRAG2 IRS1 IRS2 ITPRID2 KANK1 KCNK15 KCNK3 KCNK9 KIAA0232 KIAA0930 KIF1C KIF5B KLC2 KLC4 KLF11 KRT18 KSR1 LARP1 LATS2 LCP2 LIMK1 LYST MADD MAP2K5 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK8 MAPKAPK2 MAPT MARK2 MARK3 MARK4 MDM4 MEF2C MINK1 MLF1 MPHOSPH9 MSL2 MST1R MTNR1A MYH9 NEDD4L NFATC2 NFATC4 NR4A1 PAK1 PAK4 PARD3 PARD6A PARD6B PDC PFKFB2 PIAS1 PIK3R1 PPP1CC PPP1R14A PRDX2 PRKACA PRKAR1A PRKCA PRKCD PRKCI PRKCZ PRKD1 PRLR PRMT5 PSMA5 PTPN13 PTPRO RAF1 RALGPS2 RAP1GAP2 RASAL3 REM1 RGS3 RIN1 RMDN3 RPRD1A RRAD SAMSN1 SH3GL1 SIK1 SIK3 SIMC1 SLC8A2 SNX24 SORBS2 SQSTM1 SSX2IP STK25 STK38 SYN2 SYNPO SYNPO2 TAB2 TBC1D7 TBXA2R TERT TH TJP2 TLK2 TNFAIP3 TNS1 TP53 TPD52L1 TPH1 TRA2B TRIM21 TSC1 TSC2 TUBB UBC UBE3A UCHL5 UCP2 UCP3 USP8 VCP VIM WEE1 WNK1 WNK2 WWTR1 XRCC6 YAP1 YWHAE YWHAG ZNF839
Entrez ID		8844	7534
HPRD ID		18980	03183
Ensembl ID		ENSG00000141068	ENSG00000164924
Uniprot IDs		Q8IVT5	D0PNI1 P63104
PDB IDs		5VYK	1IB1 1QJA 1QJB 2C1J 2C1N 2O02 2WH0 3CU8 3NKX 3RDH 4BG6 4FJ3 4HKC 4IHL 4N7G 4N7Y 4N84 4WRQ 4ZDR 5D2D 5D3F 5EWZ 5EXA 5J31 5JM4 5M35 5M36 5M37 5NAS 5ULO 5WXN 5XY9 6EF5 6EJL 6EWW 6F08 6F09 6FN9 6FNA 6FNB 6FNC 6Q0K 6U2H
Enriched GO Terms of Interacting Partners?
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