HDAC4 and MEF2C

  • Number of citations of the paper that reports this interaction (PubMedID 10523670)
  • 95
  • Data Source:
  • HPRD (in vitro, in vivo)

HDAC4

MEF2C

Description histone deacetylase 4 myocyte enhancer factor 2C
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)
  • Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728)
  • Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
  • Blond vs. brown/black hair color ( 30531825)
  • Chronotype ( 30696823)
  • Diastolic blood pressure ( 30224653 30487518)
  • Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136)
  • Heel bone mineral density ( 30598549)
  • Intra-individual response time variability (selective attention) ( 30287865)
  • Male-pattern baldness ( 22693459)
  • Mean arterial pressure ( 29403010 30487518)
  • Nevus count ( 30429480)
  • Nevus count or cutaneous melanoma ( 30429480)
  • Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507)
  • Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407)
  • Pulmonary function ( 21946350)
  • Pulmonary function (smoking interaction) ( 23284291)
  • Systolic blood pressure ( 30487518)
  • Accelerometer-based physical activity measurement (average acceleration) ( 29899525)
  • Alcohol consumption ( 31358974)
  • Alcohol consumption (drinks per week) ( 30643258)
  • Alzheimer's disease ( 31473137)
  • Alzheimer's disease (late onset) ( 24162737)
  • anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Attention deficit hyperactivity disorder ( 29325848)
  • Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268)
  • Body mass index ( 26426971)
  • Bone mineral density ( 21533022 24249740 23572186)
  • Bone mineral density (hip) ( 19801982)
  • Bone mineral density (total hip) ( 29883787)
  • Bone mineral density (Ward's triangle area) ( 27397699)
  • Chronotype ( 30696823)
  • Cognitive ability ( 29186694)
  • Cognitive ability (MTAG) ( 29186694)
  • Depression ( 29700475)
  • Femoral neck bone mineral density ( 29499414 22504420)
  • General cognitive ability ( 29844566)
  • Glomerular filtration rate in chronic kidney disease ( 26420894)
  • Height ( 20881960 25282103 25429064)
  • Household income (MTAG) ( 31844048)
  • Intelligence ( 28530673)
  • Intelligence (MTAG) ( 29326435)
  • Major depressive disorder ( 27479909)
  • Mean corpuscular hemoglobin ( 27863252)
  • Mean corpuscular volume ( 27863252)
  • Mean platelet volume ( 22139419 27863252)
  • Morning person ( 30696823)
  • Multiple sclerosis ( 31604244)
  • Number of sexual partners ( 30643258)
  • Photic sneeze reflex ( 27182965)
  • Platelet count ( 22139419 27863252)
  • Platelet distribution width ( 27863252)
  • Plateletcrit ( 27863252)
  • Red blood cell count ( 27863252)
  • Regular attendance at a religious group ( 29970889)
  • Retinal arteriolar caliber ( 23776548)
  • Retinal vascular caliber ( 21060863)
  • Rosacea symptom severity ( 29771307)
  • Schizophrenia ( 25056061 30285260)
  • Smoking status (ever vs never smokers) ( 30643258)
  • Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
  • Tonometry ( 17903302)
  • Vascular endothelial growth factor levels ( 26910538)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes 88 interacting genes: ACTA1 ANKRA2 ANKRD11 APP AR ATF3 ATRX BCL6 BCOR BRMS1 CACNA1C CAMK4 CBX5 CCDC136 CDKN1A CDR2 CEBPD CIITA CSRP3 CTBP1 EFEMP2 ESR1 GATA1 GCM1 GNB1 GOLGA2 GSK3B HDAC3 HDAC7 HDAC9 HNF4A IFRD1 IKZF2 JDP2 KRT31 KRT38 KRT40 LCOR LDOC1 LZTR1 MAP1S MAPK1 MAPK3 MECOM MEF2A MEF2B MEF2C MEF2D MEGF10 MIF4GD MTUS2 NACC1 NCOR2 NFKB2 NFKBIE NPPB NR1H2 NR2C1 NR2C2 NUP155 PNMA1 PPARD PPARG PTPA RANBP2 RARA RBBP4 REV3L RFXANK RINT1 RUNX2 RUNX3 RUVBL2 RXRA SMAD3 SRF SS18L1 SUMO1 SUMO2 SYK TNFRSF14 UBE2I YWHAE YWHAG YWHAQ YWHAZ ZBTB16 ZNF354A 30 interacting genes: ASCL1 CCNB1 CDK1 COPS5 CSNK2A1 EP300 EPAS1 GATA4 HDAC4 HDAC5 HDAC7 HDAC9 MAPK14 MAPK7 MEF2D MYOD1 MYOG NCOA2 NOTCH1 PLA2G12A SMAD2 SOX18 SP1 SPTBN1 TEAD1 TWIST2 UBE2I VGLL2 VGLL4 YWHAZ
Entrez ID 9759 4208
HPRD ID 05610 02809
Ensembl ID ENSG00000068024 ENSG00000081189
Uniprot IDs P56524 A0A024RAL6 A0A024RAL7 A0A0D9SGI5 D8L7E9 Q06413
PDB IDs 2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S 5ZOO 5ZOP 6FYZ
Enriched GO Terms of Interacting Partners?
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