MEF2C and YWHAZ

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		MEF2C	YWHAZ
Description		myocyte enhancer factor 2C	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Sarcoplasm Nuclear Speck Protein-containing Complex Intracellular Membrane-bounded Organelle Postsynapse	Extracellular Space Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Focal Adhesion Vesicle Melanosome Extracellular Exosome Blood Microparticle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific AT DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Activating Transcription Factor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity HMG Box Domain Binding	RNA Binding Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ion Channel Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Blood Vessel Development Osteoblast Differentiation Neuron Migration B Cell Homeostasis Heart Looping Endochondral Ossification Blood Vessel Remodeling Chondrocyte Differentiation Germinal Center Formation Regulation Of Germinal Center Formation Primary Heart Field Specification Secondary Heart Field Specification Outflow Tract Morphogenesis Sinoatrial Valve Morphogenesis Cardiac Ventricle Formation Regulation Of Transcription, DNA-templated Apoptotic Process Humoral Immune Response Multicellular Organism Development Nervous System Development Heart Development Muscle Organ Development Skeletal Muscle Tissue Development Muscle Cell Fate Determination Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Alkaline Phosphatase Activity Neural Crest Cell Differentiation Cardiac Muscle Hypertrophy In Response To Stress Myotube Differentiation Neuron Differentiation Platelet Formation Monocyte Differentiation Negative Regulation Of Ossification Melanocyte Differentiation Positive Regulation Of Bone Mineralization Positive Regulation Of B Cell Proliferation Cellular Response To Drug Skeletal Muscle Cell Differentiation Cellular Response To Trichostatin A B Cell Proliferation Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Megakaryocyte Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Plasticity Positive Regulation Of Skeletal Muscle Tissue Development Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Embryonic Viscerocranium Morphogenesis B Cell Receptor Signaling Pathway Smooth Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Ventricular Cardiac Muscle Cell Differentiation Roof Of Mouth Development Regulation Of Synaptic Activity Positive Regulation Of Cardiac Muscle Cell Proliferation Excitatory Postsynaptic Potential Regulation Of Sarcomere Organization Cartilage Morphogenesis Regulation Of Dendritic Spine Development Renal Tubule Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cell Proliferation In Bone Marrow Glomerulus Morphogenesis Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Protein Homodimerization Activity Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Macrophage Apoptotic Process Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity Positive Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Behavioral Fear Response Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Positive Regulation Of Skeletal Muscle Cell Differentiation	Angiogenesis Respiratory System Process Protein Phosphorylation Protein Targeting Signal Transduction Synaptic Target Recognition Cytokine-mediated Signaling Pathway Platelet Activation Lung Development Tube Formation Negative Regulation Of Apoptotic Process Regulation Of MRNA Stability Establishment Of Golgi Localization Membrane Organization ERK1 And ERK2 Cascade Regulation Of ERK1 And ERK2 Cascade Regulation Of Synapse Maturation Golgi Reassembly Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		ERK/MAPK targets Transcriptional activation of mitochondrial biogenesis Circadian Clock Myogenesis MECP2 regulates transcription factors	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors
Drugs			Phenethyl Isothiocyanate
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 29325848) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Body mass index ( 26426971) Bone mineral density ( 21533022 24249740 23572186) Bone mineral density (hip) ( 19801982) Bone mineral density (total hip) ( 29883787) Bone mineral density (Ward's triangle area) ( 27397699) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Depression ( 29700475) Femoral neck bone mineral density ( 29499414 22504420) General cognitive ability ( 29844566) Glomerular filtration rate in chronic kidney disease ( 26420894) Height ( 20881960 25282103 25429064) Household income (MTAG) ( 31844048) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean platelet volume ( 22139419 27863252) Morning person ( 30696823) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Platelet count ( 22139419 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Red blood cell count ( 27863252) Regular attendance at a religious group ( 29970889) Retinal arteriolar caliber ( 23776548) Retinal vascular caliber ( 21060863) Rosacea symptom severity ( 29771307) Schizophrenia ( 25056061 30285260) Smoking status (ever vs never smokers) ( 30643258) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Tonometry ( 17903302) Vascular endothelial growth factor levels ( 26910538) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)	Adventurousness ( 30643258) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Body mass index ( 25673413) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) General risk tolerance (MTAG) ( 30643258) Interleukin-10 levels ( 22205395)
Interacting Genes		30 interacting genes: ASCL1 CCNB1 CDK1 COPS5 CSNK2A1 EP300 EPAS1 GATA4 HDAC4 HDAC5 HDAC7 HDAC9 MAPK14 MAPK7 MEF2D MYOD1 MYOG NCOA2 NOTCH1 PLA2G12A SMAD2 SOX18 SP1 SPTBN1 TEAD1 TWIST2 UBE2I VGLL2 VGLL4 YWHAZ	205 interacting genes: AANAT ABL1 ADAM22 ADRA2A ADRA2B ADRA2C AKAP13 AKT1 APP ARAF ARHGEF2 ATP5F1A ATXN1 BAD BCAR1 BCR BRAF BSPRY CBL CDC25A CDC25B CDC25C CDC5L CDK11B CDK16 CDK17 CDKN1B CENPJ CEP126 CEP131 CFL1 CGNL1 CLIC4 COP1 CRTC2 CSF2RB CSNK1A1 CSNK1D DFFA DISC1 EFNB3 EGFR EIF3A ENO1 EP300 EPB41L1 EPB41L2 EPB41L3 EXO1 FAM13B FHOD1 FOXO1 FOXO3 FOXO4 GABARAPL2 GABBR1 GCH1 GP1BA GP1BB GP5 GSK3B H3C1 HDAC4 HDAC6 HDAC9 HIVEP2 HMGN1 HSPA1A HSPA1B HSPB1 IGF1R IL9R ING1 INPP5A IRAG2 IRS1 IRS2 ITPRID2 KANK1 KCNK15 KCNK3 KCNK9 KIAA0232 KIAA0930 KIF1C KIF5B KLC2 KLC4 KLF11 KRT18 KSR1 LARP1 LATS2 LCP2 LIMK1 LYST MADD MAP2K5 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK8 MAPKAPK2 MAPT MARK2 MARK3 MARK4 MDM4 MEF2C MINK1 MLF1 MPHOSPH9 MSL2 MST1R MTNR1A MYH9 NEDD4L NFATC2 NFATC4 NR4A1 PAK1 PAK4 PARD3 PARD6A PARD6B PDC PFKFB2 PIAS1 PIK3R1 PPP1CC PPP1R14A PRDX2 PRKACA PRKAR1A PRKCA PRKCD PRKCI PRKCZ PRKD1 PRLR PRMT5 PSMA5 PTPN13 PTPRO RAF1 RALGPS2 RAP1GAP2 RASAL3 REM1 RGS3 RIN1 RMDN3 RPRD1A RRAD SAMSN1 SH3GL1 SIK1 SIK3 SIMC1 SLC8A2 SNX24 SORBS2 SQSTM1 SSX2IP STK25 STK38 SYN2 SYNPO SYNPO2 TAB2 TBC1D7 TBXA2R TERT TH TJP2 TLK2 TNFAIP3 TNS1 TP53 TPD52L1 TPH1 TRA2B TRIM21 TSC1 TSC2 TUBB UBC UBE3A UCHL5 UCP2 UCP3 USP8 VCP VIM WEE1 WNK1 WNK2 WWTR1 XRCC6 YAP1 YWHAE YWHAG ZNF839
Entrez ID		4208	7534
HPRD ID		02809	03183
Ensembl ID		ENSG00000081189	ENSG00000164924
Uniprot IDs		A0A024RAL6 A0A024RAL7 A0A0D9SGI5 D8L7E9 Q06413	D0PNI1 P63104
PDB IDs			1IB1 1QJA 1QJB 2C1J 2C1N 2O02 2WH0 3CU8 3NKX 3RDH 4BG6 4FJ3 4HKC 4IHL 4N7G 4N7Y 4N84 4WRQ 4ZDR 5D2D 5D3F 5EWZ 5EXA 5J31 5JM4 5M35 5M36 5M37 5NAS 5ULO 5WXN 5XY9 6EF5 6EJL 6EWW 6F08 6F09 6FN9 6FNA 6FNB 6FNC 6Q0K 6U2H
Enriched GO Terms of Interacting Partners?
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