PDE4DIP and TNIK

Number of citations of the paper that reports this interaction (PubMedID 17043677)
168

Data Source:
BioGRID (two hybrid)

		PDE4DIP	TNIK
Description		phosphodiesterase 4D interacting protein	TRAF2 and NCK interacting kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Centrosome Myofibril	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Protein Binding Enzyme Binding Molecular Adaptor Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Cellular Protein-containing Complex Assembly Regulation Of Golgi Organization	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Regulation Of Mitotic Cell Cycle Wnt Signaling Pathway Signal Transduction By Protein Phosphorylation Microvillus Assembly Stress-activated Protein Kinase Signaling Cascade Actin Cytoskeleton Reorganization Activation Of Protein Kinase Activity Intracellular Signal Transduction Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways			Oxidative Stress Induced Senescence
Drugs
Diseases
GWAS		Capecitabine sensitivity ( 22864933)	Adolescent idiopathic scoliosis ( 28334814) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Cerebrospinal fluid AB1-42 levels ( 29274321) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Frontotemporal dementia (age at onset) ( 29724592) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol ( 21347282) Lymphocyte counts ( 27863252) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment in schizophrenia ( 29503163) Type 2 diabetes ( 30054458)
Interacting Genes		76 interacting genes: ADH1B AEN ANKRD11 ARNT2 BYSL C1orf109 CCDC146 CCDC198 CDC5L CDKN1A CHCHD3 CHD1L EGR2 EIF4E2 FAM161A FAM74A4 FCHSD2 FES FHL1 GADD45G GBE1 GFI1B GNRHR2 GOLGA5 GOLGA8EP GOLGA8F HAUS1 IMMT ITSN2 KDM1A KLC3 KLC4 KRAS KRT1 KRT18 KRT31 LAMTOR3 LENG1 LMO4 MIF4GD MTUS2 NAA10 NEFL NEK2 OSGEP PDE4D PEA15 PFDN1 PIAS4 PPP1R18 PRNP PRPF31 RBM8A RTP5 SCNM1 SDCBP SH2D4A SHFL SMN1 SNCA TEAD4 TFIP11 THRB TK1 TMOD4 TNIK TRAF4 UTP14C VAC14 ZBTB38 ZDHHC17 ZFYVE21 ZNF408 ZNF512B ZNF581 ZSCAN26	37 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1
Entrez ID		9659	23043
HPRD ID		10482	18206
Ensembl ID		ENSG00000178104	ENSG00000154310
Uniprot IDs		A0A075B749 A0A087WYE4 Q5VU43	Q9UKE5
PDB IDs			2X7F 5AX9 5CWZ 5D7A 6RA7
Enriched GO Terms of Interacting Partners?
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