TJP2 and CTNNA1

Number of citations of the paper that reports this interaction (PubMedID 10026224)
62

Data Source:
HPRD (in vitro)

		TJP2	CTNNA1
Description		tight junction protein 2	catenin alpha 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Cell-cell Contact Zone	Acrosomal Vesicle Cytosol Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Catenin Complex Flotillin Complex Lamellipodium Cell Junction Intracellular Membrane-bounded Organelle
	Molecular Function	Guanylate Kinase Activity Protein Binding Protein Domain Specific Binding Protein Binding, Bridging Cadherin Binding Protein Tyrosine Kinase Binding	RNA Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Vinculin Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding
	Biological Process	Homotypic Cell-cell Adhesion Hippo Signaling GMP Metabolic Process GDP Metabolic Process Intestinal Absorption Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Positive Regulation Of Maintenance Of Permeability Of Blood-brain Barrier	Ovarian Follicle Development Cell Adhesion Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Neuroblast Proliferation Aging Male Gonad Development Gap Junction Assembly Axon Regeneration Adherens Junction Organization Cellular Protein Localization Odontogenesis Of Dentin-containing Tooth Apical Junction Assembly Response To Estrogen Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Muscle Cell Differentiation Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by Hippo Apoptotic cleavage of cell adhesion proteins	Adherens junctions interactions VEGFR2 mediated vascular permeability Myogenesis Myogenesis RHO GTPases activate IQGAPs
Drugs
Diseases
GWAS		Macular thickness ( 30535121) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 23396134) Renal sinus fat ( 22044751) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	General risk tolerance (MTAG) ( 30643258) Schizophrenia ( 25056061)
Interacting Genes		17 interacting genes: CDK6 CGN CLDN1 CLDN2 CLK1 CTNNA1 EPB41 HGS HSPB1 SAFB SCRIB SH3KBP1 SRPK2 TJP1 YWHAB YWHAG YWHAZ	31 interacting genes: ACTN1 AFDN AJUBA APC APP ARMC8 CA9 CDH1 CDH15 CDH2 CDH3 CDH5 CSNK2A1 CTBP1 CTNNB1 DLG1 JUP LRATD2 MTNR1A MTNR1B OBI1 PKD1 PSEN1 SASH1 SPTAN1 SPTBN1 TJP1 TJP2 UBE2I VCL ZGPAT
Entrez ID		9414	1495
HPRD ID		06369	00285
Ensembl ID		ENSG00000119139	ENSG00000044115
Uniprot IDs		B7Z2R3 B7Z954 Q9UDY2	A0A384MDY0 B4DKT9 B4DU00 G3XAM7 P35221
PDB IDs		2OSG 3E17	1H6G 4EHP 4IGG
Enriched GO Terms of Interacting Partners?
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