CTNNA1 and CDH2

Number of citations of the paper that reports this interaction (PubMedID 12604612)
43

Data Source:
HPRD (in vitro)

		CTNNA1	CDH2
Description		catenin alpha 1	cadherin 2
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytosol Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Catenin Complex Flotillin Complex Lamellipodium Cell Junction Intracellular Membrane-bounded Organelle	Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell Surface Postsynaptic Density Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Catenin Complex Lamellipodium Cell Junction Cortical Actin Cytoskeleton Sarcolemma Neuron Projection Plasma Membrane Raft Apical Part Of Cell Synapse Collagen-containing Extracellular Matrix Integral Component Of Presynaptic Active Zone Membrane Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	RNA Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Vinculin Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding	Calcium Ion Binding Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Protein Kinase Binding Protein Phosphatase Binding Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding
	Biological Process	Ovarian Follicle Development Cell Adhesion Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Neuroblast Proliferation Aging Male Gonad Development Gap Junction Assembly Axon Regeneration Adherens Junction Organization Cellular Protein Localization Odontogenesis Of Dentin-containing Tooth Apical Junction Assembly Response To Estrogen Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Muscle Cell Differentiation Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cell Morphogenesis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Multicellular Organism Development Synapse Assembly Brain Development Glial Cell Differentiation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Cerebral Cortex Development Adherens Junction Organization Positive Regulation Of MAPK Cascade Post-translational Protein Modification Cellular Protein Metabolic Process Cell-cell Adhesion Mediated By Cadherin Blood Vessel Morphogenesis Brain Morphogenesis Homeostasis Of Number Of Cells Regulation Of Axonogenesis Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Regulation Of Synaptic Transmission, Glutamatergic Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Neuronal Stem Cell Population Maintenance Cell-cell Adhesion Regulation Of Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Myogenesis Myogenesis RHO GTPases activate IQGAPs	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Adherens junctions interactions Myogenesis Myogenesis Post-translational protein phosphorylation
Drugs
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Schizophrenia ( 25056061)	Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Lung function (FVC) ( 24023788) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Periodontal disease-related phenotype (Socransky) ( 24347629) Response to hepatitis B vaccine ( 29534301) Resting heart rate ( 27798624) Temperament (bipolar disorder) ( 22365631) Type 2 diabetes ( 31049640) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) vWF and FVIII levels ( 21810271)
Interacting Genes		31 interacting genes: ACTN1 AFDN AJUBA APC APP ARMC8 CA9 CDH1 CDH15 CDH2 CDH3 CDH5 CSNK2A1 CTBP1 CTNNB1 DLG1 JUP LRATD2 MTNR1A MTNR1B OBI1 PKD1 PSEN1 SASH1 SPTAN1 SPTBN1 TJP1 TJP2 UBE2I VCL ZGPAT	23 interacting genes: ARHGAP32 ARVCF BOC CDH11 CDH4 CDON CREBBP CTNNA1 CTNNB1 CTNND2 EXOC5 FGFR4 GNA12 GNA13 GRIK2 GRIN1 GRIN2D JUP LRRC7 PIK3R1 PKP4 PTPN1 UBC
Entrez ID		1495	1000
HPRD ID		00285	00226
Ensembl ID		ENSG00000044115	ENSG00000170558
Uniprot IDs		A0A384MDY0 B4DKT9 B4DU00 G3XAM7 P35221	A0A024RC42 P19022
PDB IDs		1H6G 4EHP 4IGG
Enriched GO Terms of Interacting Partners?
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