LATS1 and NUAK1

Number of citations of the paper that reports this interaction (PubMedID 19927127)
31

Data Source:
BioGRID (enzymatic study)

		LATS1	NUAK1
Description		large tumor suppressor kinase 1	NUAK family kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Microtubule Organizing Center Cytosol	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Estrogen Receptor Binding	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Hormone-mediated Signaling Pathway Peptidyl-serine Phosphorylation Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Protein Localization Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cytoplasmic Sequestering Of Protein Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Adhesion Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Intracellular Signal Transduction Regulation Of Cell Proliferation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cellular Senescence
Pathways		Signaling by Hippo	Regulation of TP53 Activity through Phosphorylation
Drugs
Diseases
GWAS		Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Testicular germ cell tumor ( 28604728)	Alzheimer's disease biomarkers ( 23419831) Attention function in attention deficit hyperactive disorder ( 26174813) General glucose level in pregnancy (gestational week 30-32) ( 30324795) Lateral ventricular volume in normal aging ( 30258056) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Two-hour glucose in pregnancy (gestational week 30-32) ( 30324795)
Interacting Genes		45 interacting genes: ALPP APP AURKB CAV1 CBY2 CDC26 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LRRK2 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NF2 NUAK1 NUAK2 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 UBE2I WWOX WWP1 WWTR1 ZYX	7 interacting genes: APP CASP6 FBXO25 LATS1 MARK2 MRPS25 PPP1CC
Entrez ID		9113	9891
HPRD ID		09147	12171
Ensembl ID		ENSG00000131023	ENSG00000074590
Uniprot IDs		O95835	A0A024RBL3 O60285
PDB IDs		4ZRK 5B5W 5BRK
Enriched GO Terms of Interacting Partners?
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