LATS1 and PPP1R11

Number of citations of the paper that reports this interaction (PubMedID 22641346)
24

Data Source:
BioGRID (enzymatic study)

		LATS1	PPP1R11
Description		large tumor suppressor kinase 1	protein phosphatase 1 regulatory inhibitor subunit 11
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Microtubule Organizing Center Cytosol	Nucleus Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Estrogen Receptor Binding	Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Ubiquitin Protein Ligase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Hormone-mediated Signaling Pathway Peptidyl-serine Phosphorylation Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Protein Localization Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cytoplasmic Sequestering Of Protein Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Protein Dephosphorylation Negative Regulation Of Cytokine Secretion Defense Response To Gram-positive Bacterium
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS		Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Testicular germ cell tumor ( 28604728)	Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Lipid metabolism phenotypes ( 22286219)
Interacting Genes		45 interacting genes: ALPP APP AURKB CAV1 CBY2 CDC26 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LRRK2 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NF2 NUAK1 NUAK2 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 UBE2I WWOX WWP1 WWTR1 ZYX	4 interacting genes: LATS1 PPP1CA UBXN2B VCP
Entrez ID		9113	6992
HPRD ID		09147	09449
Ensembl ID		ENSG00000131023	ENSG00000204619
Uniprot IDs		O95835	A2BEK1 O60927
PDB IDs		4ZRK 5B5W 5BRK
Enriched GO Terms of Interacting Partners?
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