HERC1 and LAPTM5

Number of citations of the paper that reports this interaction (PubMedID 15231748)
85

Data Source:
HPRD (two hybrid)

		HERC1	LAPTM5
Description		HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	lysosomal protein transmembrane 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Membrane	Lysosome Lysosomal Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity ARF Guanyl-nucleotide Exchange Factor Activity	Protein Binding
	Biological Process	Negative Regulation Of Autophagy Protein Ubiquitination Cerebellar Purkinje Cell Differentiation Corpus Callosum Development Neuron Projection Development Neuromuscular Process Controlling Balance	Cellular Response To Leukemia Inhibitory Factor
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Glucagon levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Iris characteristics ( 21835309) Reticulocyte fraction of red cells ( 27863252)	Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369)
Interacting Genes		12 interacting genes: BAK1 EP300 LAPTM5 PKM RAF1 RNF11 SOX9 UBC UBE2D2 UBE2D3 UBE2L3 UBE2S	25 interacting genes: ANKRD13A DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 HERC1 HEY1 HEYL HUWE1 ITCH KRT7 LDLRAD1 NEDD4 NEDD4L RNF168 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC USP13 WWP1
Entrez ID		8925	7805
HPRD ID		06894	03280
Ensembl ID		ENSG00000103657	ENSG00000162511
Uniprot IDs		A0A024R5W0 Q15751	Q13571 Q5TBB8
PDB IDs		4O2W 4QT6
Enriched GO Terms of Interacting Partners?
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