HESX1 and PROP1

Number of citations of the paper that reports this interaction (PubMedID 11283314)
25

Data Source:
HPRD (in vivo)

		HESX1	PROP1
Description		HESX homeobox 1	PROP paired-like homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nuclear Chromatin Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Protein C-terminus Binding Protein N-terminus Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Brain Development Pituitary Gland Development Otic Vesicle Formation Nose Development Forebrain Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Central Nervous System Development Dorsal/ventral Pattern Formation Cell Migration Hypothalamus Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Hypophysis Morphogenesis Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation
Pathways
Drugs
Diseases		Septo-optic dysplasia Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256)
Interacting Genes		7 interacting genes: KDM1A NCOR1 NPAS2 PRMT6 PROP1 STAT3 TLE1	2 interacting genes: HESX1 PITX2
Entrez ID		8820	5626
HPRD ID		03482	03325
Ensembl ID		ENSG00000163666	ENSG00000175325
Uniprot IDs		A1LQR0 Q9UBX0	A0A0G2JQ02 O75360
PDB IDs		2K40
Enriched GO Terms of Interacting Partners?
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