PROP1 and PITX2

Number of citations of the paper that reports this interaction (PubMedID 9685346)
47

Data Source:
HPRD (in vitro)

		PROP1	PITX2
Description		PROP paired-like homeobox 1	paired like homeodomain 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Transcription Factor Complex	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Central Nervous System Development Dorsal/ventral Pattern Formation Cell Migration Hypothalamus Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Hypophysis Morphogenesis Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation	Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Anatomical Structure Morphogenesis Hair Cell Differentiation Deltoid Tuberosity Development Odontogenesis Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification
Pathways			TFAP2 (AP-2) family regulates transcription of other transcription factors
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Axenfeld-Rieger syndrome (ARS)
GWAS			Appendicitis ( 30392061) Atrial fibrillation ( 28416818 28416822 29290336 30061737 29892015 20173747 19597492 22544366) Atrial fibrillation/atrial flutter ( 17603472) Cognitive decline rate in late mild cognitive impairment ( 26252872) Early onset atrial fibrillation ( 28460022) Heart failure ( 31919418) Incident atrial fibrillation ( 28416818) Intraocular pressure ( 29235454) Ischemic stroke ( 24262325 26708676 29531354) Ischemic stroke (cardioembolic) ( 27068588 26708676 29531354) Lung cancer ( 28604730) Prevalent atrial fibrillation ( 28416818) Smoking status (heavy vs never) ( 26423011) Stroke ( 29531354) Stroke (ischemic) ( 23041239)
Interacting Genes		2 interacting genes: HESX1 PITX2	9 interacting genes: CTNNB1 HDAC1 HERC5 KAT5 LEF1 PDLIM1 PROP1 TRIM25 ZNHIT3
Entrez ID		5626	5308
HPRD ID		03325	03328
Ensembl ID		ENSG00000175325	ENSG00000164093
Uniprot IDs		A0A0G2JQ02 O75360	Q99697
PDB IDs			2L7F 2L7M 2LKX
Enriched GO Terms of Interacting Partners?
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