PROP1 and HESX1

Number of citations of the paper that reports this interaction (PubMedID 11283314)
25

Data Source:
HPRD (in vivo)

		PROP1	HESX1
Description		PROP paired-like homeobox 1	HESX homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Transcription Factor Complex	Nuclear Chromatin Nucleus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Protein C-terminus Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Central Nervous System Development Dorsal/ventral Pattern Formation Cell Migration Hypothalamus Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Hypophysis Morphogenesis Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Brain Development Pituitary Gland Development Otic Vesicle Formation Nose Development Forebrain Morphogenesis
Pathways
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Septo-optic dysplasia Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS			Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256)
Interacting Genes		2 interacting genes: HESX1 PITX2	7 interacting genes: KDM1A NCOR1 NPAS2 PRMT6 PROP1 STAT3 TLE1
Entrez ID		5626	8820
HPRD ID		03325	03482
Ensembl ID		ENSG00000175325	ENSG00000163666
Uniprot IDs		A0A0G2JQ02 O75360	A1LQR0 Q9UBX0
PDB IDs			2K40
Enriched GO Terms of Interacting Partners?
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