PPFIA2 and GIT1

Number of citations of the paper that reports this interaction (PubMedID 12629171)
61

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PPFIA2	GIT1
Description		PTPRF interacting protein alpha 2	GIT ArfGAP 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Surface Cell Junction Axon Dendritic Spine Presynaptic Active Zone Extracellular Exosome Glutamatergic Synapse	Mitochondrion Cytosol Focal Adhesion Membrane Calyx Of Held
	Molecular Function	Protein Binding Structural Constituent Of Presynapse	GTPase Activator Activity Protein Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Cell-matrix Adhesion Neurotransmitter Secretion Glutamate Secretion Synapse Organization Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Presynapse Organization Dense Core Granule Cytoskeletal Transport Regulation Of Synaptic Vesicle Exocytosis	Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases	Ephrin signaling Ephrin signaling Activation of RAC1 downstream of NMDARs
Drugs
Diseases
GWAS		Age-related cataracts (age at onset) ( 25352737) Alcohol dependence ( 26365420) Delirium ( 29631748) Lean body mass ( 28552196) Post bronchodilator FEV1 ( 26634245) Resting heart rate ( 27798624) Schizophrenia ( 22885689)
Interacting Genes		13 interacting genes: CAST CDC5L ERC2 GIT1 ITSN1 MTDH PPFIA1 PPFIA3 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRS	52 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CENPU CEP126 CHD3 DDX24 EIF6 ENTR1 GIT2 GPAA1 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HTT KIF1A LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG
Entrez ID		8499	28964
HPRD ID		04392	06577
Ensembl ID		ENSG00000139220	ENSG00000108262
Uniprot IDs		B7Z7Y5 G3V200 H0YHK3 O75334 Q4LE62	Q59FC3 Q9Y2X7
PDB IDs		3TAC 3TAD 6IUH
Enriched GO Terms of Interacting Partners?
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