TRIM55 and PIAS2

Number of citations of the paper that reports this interaction (PubMedID 18157088)
67

Data Source:
BioGRID (two hybrid)

		TRIM55	PIAS2
Description		tripartite motif containing 55	protein inhibitor of activated STAT 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule	Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Signal Transduction	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Coronary heart disease event reduction (statin therapy interaction) ( 22666496) Metabolite levels ( 23823483) Recurrent major depressive disorder ( 29317602)
Interacting Genes		62 interacting genes: ACTA1 ANKRD1 ATP5F1B ATXN3 ATXN3L BRAP CKM DCAF6 DES EEF1G EHHADH EIF3E ESPL1 FHL2 FLNA FLNB FLNC GFM1 GMEB1 LMCD1 MDM4 MRPL19 MRPL41 MYBPC1 MYBPC3 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 OTUB1 OTUB2 PCGF1 PIAS1 PIAS2 PIAS3 RNF114 SQSTM1 STAM TCAP TNNI1 TNNI2 TNNI3 TRIM27 TRIM54 TRIM63 TTN UBE2D1 UBE2D2 UBE2D3 UBE2L3 UCHL3 UCHL5 USP13 USP28 USP4 USP5 USP7 USP8 UXT YOD1	72 interacting genes: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CDCA8 CHMP4B CLDN2 CREBBP CTBP1 DDX39B DNMT3A ELK1 ESR1 ESR2 FLI1 GFAP GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 JUN LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I UBE2L3 ZBED1 ZBTB8A ZNF451
Entrez ID		84675	9063
HPRD ID		05927	06944
Ensembl ID		ENSG00000147573	ENSG00000078043
Uniprot IDs		Q9BYV6	A0A024RC49 O75928 Q2TA77
PDB IDs			2ASQ 4FO9
Enriched GO Terms of Interacting Partners?
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