PIAS2 and CHMP4B

Number of citations of the paper that reports this interaction (PubMedID 16730941)
60

Data Source:
HPRD (two hybrid)

		PIAS2	CHMP4B
Description		protein inhibitor of activated STAT 2	charged multivesicular body protein 4B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm PML Body Nuclear Speck	ESCRT III Complex Cell Nucleus Nuclear Envelope Cytoplasm Endosome Cytosol Cytoplasmic Side Of Plasma Membrane Membrane Coat Midbody Late Endosome Membrane Vesicle Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway	Mitotic Cytokinesis Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Exit From Mitosis Regulation Of Centrosome Duplication Endosomal Transport Macroautophagy Viral Life Cycle Nuclear Envelope Reassembly Multivesicular Body Assembly Maintenance Of Lens Transparency Viral Budding Via Host ESCRT Complex Viral Budding Regulation Of Viral Process Protein Polymerization Negative Regulation Of Cell Death Midbody Abscission Membrane Fission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Neuron Death Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Negative Regulation Of Autophagosome Assembly
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases
GWAS			Feeling nervous ( 29500382) Loneliness ( 27629369) Offspring birth weight ( 31043758) Stearic acid (18:0) levels ( 23362303)
Interacting Genes		72 interacting genes: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CDCA8 CHMP4B CLDN2 CREBBP CTBP1 DDX39B DNMT3A ELK1 ESR1 ESR2 FLI1 GFAP GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 JUN LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I UBE2L3 ZBED1 ZBTB8A ZNF451	15 interacting genes: CHMP1B CHMP3 CHMP4A CHMP4C CHMP5 CHMP6 EXOSC9 HIPK2 NOD2 PDCD6IP PIAS2 PTPN23 STAMBP UBE2I VPS4A
Entrez ID		9063	128866
HPRD ID		06944	16642
Ensembl ID		ENSG00000078043	ENSG00000101421
Uniprot IDs		A0A024RC49 O75928 Q2TA77	Q9H444
PDB IDs		2ASQ 4FO9	3C3Q 3UM3 4ABM 5MK2
Enriched GO Terms of Interacting Partners?
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