TRIM55 and TNNI3

Number of citations of the paper that reports this interaction (PubMedID 18157088)
67

Data Source:
BioGRID (two hybrid)

		TRIM55	TNNI3
Description		tripartite motif containing 55	troponin I3, cardiac type
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule	Cell Cytosol Troponin Complex Sarcomere Cardiac Myofibril Cardiac Troponin Complex
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Metal Ion Binding Calcium-dependent Protein Binding Actin Filament Binding
	Biological Process	Signal Transduction	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Skeletal Muscle Contraction Cellular Calcium Ion Homeostasis Muscle Contraction Regulation Of Smooth Muscle Contraction Heart Development Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Muscle Filament Sliding Negative Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction
Pathways			Striated Muscle Contraction Ion homeostasis
Drugs			N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases			Hypertrophic cardiomyopathy (HCM)
GWAS		Coronary heart disease event reduction (statin therapy interaction) ( 22666496) Metabolite levels ( 23823483) Recurrent major depressive disorder ( 29317602)
Interacting Genes		62 interacting genes: ACTA1 ANKRD1 ATP5F1B ATXN3 ATXN3L BRAP CKM DCAF6 DES EEF1G EHHADH EIF3E ESPL1 FHL2 FLNA FLNB FLNC GFM1 GMEB1 LMCD1 MDM4 MRPL19 MRPL41 MYBPC1 MYBPC3 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 OTUB1 OTUB2 PCGF1 PIAS1 PIAS2 PIAS3 RNF114 SQSTM1 STAM TCAP TNNI1 TNNI2 TNNI3 TRIM27 TRIM54 TRIM63 TTN UBE2D1 UBE2D2 UBE2D3 UBE2L3 UCHL3 UCHL5 USP13 USP28 USP4 USP5 USP7 USP8 UXT YOD1	18 interacting genes: ACTA1 HSPB2 LYST MST1 PAPPA PKD2 PKD2L1 PRKCA PSMC5 RCAN3 SOX4 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63
Entrez ID		84675	7137
HPRD ID		05927	11769
Ensembl ID		ENSG00000147573	ENSG00000129991
Uniprot IDs		Q9BYV6	P19429 Q6FGX2
PDB IDs			1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R 2MZP 2N7L 4Y99 5VLN 5W88 5WCL 6MV3
Enriched GO Terms of Interacting Partners?
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