RECK and SIGMAR1

		RECK	SIGMAR1
Description		reversion inducing cysteine rich protein with kazal motifs	sigma non-opioid intracellular receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Anchored Component Of Membrane Wnt Signalosome	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Plasma Membrane Postsynaptic Density Integral Component Of Membrane Cell Junction Growth Cone Cytoplasmic Vesicle Postsynaptic Density Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Wnt-protein Binding Coreceptor Activity Involved In Canonical Wnt Signaling Pathway	Opioid Receptor Activity Protein Binding Drug Binding
	Biological Process	Vasculature Development Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity	Lipid Transport Nervous System Development Cell Death In Response To Hydrogen Peroxide Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Protein Homotrimerization
Pathways		Post-translational modification: synthesis of GPI-anchored proteins
Drugs			Amitriptyline Remoxipride Dextromethorphan Nortriptyline Pentazocine Cocaine Dimethyltryptamine Prasterone Phencyclidine Captodiame
Diseases
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)
Interacting Genes		15 interacting genes: CEP44 CTH KEAP1 KRT40 MEOX2 MMP9 MTNR1B NOTCH2NLA REL SIGMAR1 TCF4 TEKT4 TRIM39 TRIM69 USHBP1	13 interacting genes: ANK2 DCAF12 DNAJB5 GNE ITPR3 NFX1 PDZD11 PHF24 RECK RUSC2 SPAG8 SPINK4 VCP
Entrez ID		8434	10280
HPRD ID		05567	03580
Ensembl ID		ENSG00000122707	ENSG00000147955
Uniprot IDs		A8K9D8 O95980 Q6P9E2	A2A3U5 B4DR71 Q99720
PDB IDs			5HK1 5HK2 6DJZ 6DK0 6DK1
Enriched GO Terms of Interacting Partners?
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