SIGMAR1 and RECK

		SIGMAR1	RECK
Description		sigma non-opioid intracellular receptor 1	reversion inducing cysteine rich protein with kazal motifs
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Plasma Membrane Postsynaptic Density Integral Component Of Membrane Cell Junction Growth Cone Cytoplasmic Vesicle Postsynaptic Density Membrane	Extracellular Region Plasma Membrane Membrane Anchored Component Of Membrane Wnt Signalosome
	Molecular Function	Opioid Receptor Activity Protein Binding Drug Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Wnt-protein Binding Coreceptor Activity Involved In Canonical Wnt Signaling Pathway
	Biological Process	Lipid Transport Nervous System Development Cell Death In Response To Hydrogen Peroxide Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Protein Homotrimerization	Vasculature Development Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity
Pathways			Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Amitriptyline Remoxipride Dextromethorphan Nortriptyline Pentazocine Cocaine Dimethyltryptamine Prasterone Phencyclidine Captodiame
Diseases
GWAS			Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)
Interacting Genes		13 interacting genes: ANK2 DCAF12 DNAJB5 GNE ITPR3 NFX1 PDZD11 PHF24 RECK RUSC2 SPAG8 SPINK4 VCP	15 interacting genes: CEP44 CTH KEAP1 KRT40 MEOX2 MMP9 MTNR1B NOTCH2NLA REL SIGMAR1 TCF4 TEKT4 TRIM39 TRIM69 USHBP1
Entrez ID		10280	8434
HPRD ID		03580	05567
Ensembl ID		ENSG00000147955	ENSG00000122707
Uniprot IDs		A2A3U5 B4DR71 Q99720	A8K9D8 O95980 Q6P9E2
PDB IDs		5HK1 5HK2 6DJZ 6DK0 6DK1
Enriched GO Terms of Interacting Partners?
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