SLA2 and LAMC2

Number of citations of the paper that reports this interaction (PubMedID 17353186)
11

Data Source:
BioGRID (far western blotting)

		SLA2	LAMC2
Description		Src like adaptor 2	laminin subunit gamma 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Late Endosome Golgi Apparatus Plasma Membrane Phosphatidylinositol 3-kinase Complex Endosome Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Basement Membrane Laminin-2 Complex Extracellular Space Cell Cortex Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein N-terminus Binding	Extracellular Matrix Structural Constituent Heparin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signal Transduction B Cell Mediated Immunity Intracellular Receptor Signaling Pathway T Cell Activation Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphorylation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Antigen Receptor-mediated Signaling Pathway Negative Regulation Of B Cell Activation	Cell Adhesion Motor Neuron Axon Guidance Positive Regulation Of Cell Proliferation Epidermis Development Animal Organ Morphogenesis Tissue Development Dendrite Development Extracellular Matrix Organization Positive Regulation Of Cell Migration Hemidesmosome Assembly
Pathways			Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling
Drugs
Diseases			Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS			Acne (severe) ( 30542056) Blood protein levels ( 30072576 29875488) Clozapine-induced agranulocytosis ( 25187353) HDL cholesterol ( 21347282) Morning person ( 30696823) Systemic lupus erythematosus ( 21408207)
Interacting Genes		7 interacting genes: CBL CD247 CSF1 EGFR ERBB2 LAMC2 ZAP70	8 interacting genes: BMP1 COL7A1 CSF1R FBLN2 LAMB3 NID1 SCAP SLA2
Entrez ID		84174	3918
HPRD ID		05955	01031
Ensembl ID		ENSG00000101082	ENSG00000058085
Uniprot IDs		Q9H6Q3	Q13753
PDB IDs		4M4Z
Enriched GO Terms of Interacting Partners?
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