LAMC2 and NID1

Number of citations of the paper that reports this interaction (PubMedID 11733994)
31

Data Source:
HPRD (in vitro)

		LAMC2	NID1
Description		laminin subunit gamma 2	nidogen 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-2 Complex Extracellular Space Cell Cortex Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix	Extracellular Region Basement Membrane Plasma Membrane Receptor Complex Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Heparin Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Collagen Binding Wnt-protein Binding Wnt-activated Receptor Activity Laminin Binding Laminin-1 Binding Proteoglycan Binding
	Biological Process	Cell Adhesion Motor Neuron Axon Guidance Positive Regulation Of Cell Proliferation Epidermis Development Animal Organ Morphogenesis Tissue Development Dendrite Development Extracellular Matrix Organization Positive Regulation Of Cell Migration Hemidesmosome Assembly	Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Glomerular Basement Membrane Development Canonical Wnt Signaling Pathway Basement Membrane Organization
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling	Degradation of the extracellular matrix Degradation of the extracellular matrix Laminin interactions Laminin interactions
Drugs			Urokinase
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Acne (severe) ( 30542056) Blood protein levels ( 30072576 29875488) Clozapine-induced agranulocytosis ( 25187353) HDL cholesterol ( 21347282) Morning person ( 30696823) Systemic lupus erythematosus ( 21408207)	Blood protein levels ( 30072576) Cutaneous nevi ( 21478494) Diverticulitis ( 28585551) Urate levels in overweight individuals ( 25811787)
Interacting Genes		8 interacting genes: BMP1 COL7A1 CSF1R FBLN2 LAMB3 NID1 SCAP SLA2	21 interacting genes: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL
Entrez ID		3918	4811
HPRD ID		01031	00574
Ensembl ID		ENSG00000058085	ENSG00000116962
Uniprot IDs		Q13753	P14543
PDB IDs			1NDX
Enriched GO Terms of Interacting Partners?
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