PCBD2 and HES4

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		PCBD2	HES4
Description		pterin-4 alpha-carbinolamine dehydratase 2	hes family bHLH transcription factor 4
Image			No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus	Nuclear Chromatin Nucleus
	Molecular Function	Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Transcription Factor Binding Protein Dimerization Activity E-box Binding N-box Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Oxidation-reduction Process	Negative Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Cell Differentiation Negative Regulation Of Neuron Differentiation
Pathways
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 28552196 18391951) Type 2 diabetes ( 24509480)
Interacting Genes		33 interacting genes: AATF APP ASCC2 BRF1 C1D CDC5L CENPK CHAF1A F2RL1 FBXO7 GTF2E1 HES4 IRF2BP1 KCNIP3 MAGEA11 MED21 MED30 MED4 MED7 MET PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SSX3 SSX5 STAT3 TAL2 TGIF2LY XBP1 ZZZ3	5 interacting genes: COPG2 LTN1 PCBD1 PCBD2 RGS3
Entrez ID		84105	57801
HPRD ID		17824	16273
Ensembl ID		ENSG00000132570	ENSG00000188290
Uniprot IDs		Q9H0N5	D6REB3 E9PB28 Q9HCC6
PDB IDs		4C45
Enriched GO Terms of Interacting Partners?
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